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Georg Tzimas

Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption
1996 · Thomas Arnhold, Georg Tzimas, et al. · Life Sciences · 88
Comparative Teratology and Transplacental Pharmacokinetics of All-trans-Retinoic Acid, 13-cis-Retinoic Acid, and Retinyl Palmitate Following Daily Administrations in Rats
1994 · M.D. Collins, G. Tzimas, et al. · Toxicology and Applied Pharmacology · 79
The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use
1997 · Louise Latriano, Georg Tzimas, et al. · Journal of the American Academy of Dermatology · 64
Endogenous Status of Retinoids and Their Cytosolic Binding Proteins in Limb Buds of Chick vs Mouse Embryos
1994 · William J. Scott, Rosemarie Walter, et al. · Developmental Biology · 61
The Role of Metabolism and Toxicokinetics in Retinoid Teratogenesis
2001 · Georg Tzimas, Heinz Nau · Current Pharmaceutical Design · 57
Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium.
1999 · J C Tsibris, K B Porter, et al. · PubMed · 57
The Area under the Concentration–Time Curve of All-trans-Retinoic Acid Is the Most Suitable Pharmacokinetic Correlate to the Embryotoxicity of This Retinoid in the Rat
1997 · Georg Tzimas, Renate Thiel, et al. · Toxicology and Applied Pharmacology · 53
The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid
1994 · Georg Tzimas, Heinrich Bürgin, et al. · Archives of Toxicology · 47
Modulation of myb gene expression in sponges by retinoic acid.
1992 · H K Biesalski, G Doepner, et al. · PubMed · 47
Antiepileptic drugs alter endogenous retinoid concentrations: A possible mechanism of teratogenesis of anticonvulsant therapy
1995 · H. Nau, G. Tzimas, et al. · Life Sciences · 45
Identification of 9,13-dicis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-dicis-retinoic acid to the mouse and rat embryos.
1994 · G Tzimas, J O Sass, et al. · Drug Metabolism and Disposition · 45
Paronychia with Pyogenic Granuloma in a Child Treated with Indinavir: The Retinoid-Mediated Side Effect Theory Revisited
2000 · J.O. Sass, B. Jakob-Sölder, et al. · Dermatology · 41
Embryotoxic Doses of Vitamin A to Rabbits Result in Low Plasma but High Embryonic Concentrations of All-trans-Retinoic Acid: Risk of Vitamin A Exposure in Humans
1996 · Georg Tzimas, Michael D. Collins, et al. · Journal of Nutrition · 38
Single Versus Multiple Dose Administration of All-trans-retinoic Acid during Organogenesis: Differential Metabolism and Transplacental Kinetics in Rat and Rabbit
1995 · M.D. Collins, G. Tzimas, et al. · Toxicology and Applied Pharmacology · 31
Developmental Stage-Associated Differences in the Transplacental Distribution of 13-cis-Retinoic and All-trans-Retinoic Acid as Well as Their Glucuronides in Rats and Mice
1995 · G. Tzimas, M.D. Collins, et al. · Toxicology and Applied Pharmacology · 27
Retinoid teratogenicity in the macaque: Verification of dosing regimen
1998 · A.G. Hendrickx, G. Tzimas, et al. · Journal of Medical Primatology · 21
Retinoid metabolism and transplacental pharmacokinetics in the cynomolgus monkey following a nonteratogenic dosing regimen with all-trans-retinoic acid
1996 · Georg Tzimas, Heinz Nau, et al. · Teratology · 19
Identification of 14-hydroxy-4,14-retro-retinol as an in vivo metabolite of vitamin A
1996 · Georg Tzimas, Michael D. Collins, et al. · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 18
9-Cis-retinoyl-β-glucuronide is a major metabolite of 9-Cis-retinoic acid
1994 · Jörn Oliver Sass, Georg Tzimas, et al. · Life Sciences · 18
Metabolism of Retinaldehyde Isomers in Pregnant Rats: 13-cis- and all-trans-Retinaldehyde, but not 9-cis-Retinaldehyde, Yield Very Similar Patterns of Retinoid Metabolites
1999 · Jörn Oliver Sass, Georg Tzimas, et al. · Drug Metabolism and Disposition · 13
Distribution of endogenous retinoids, retinoid binding proteins (RBP, CRABPI) and nuclear retinoid X receptor ? (RXR?) in the porcine embryo
2002 · Florian J. Schweigert, Christiane Siegling, et al. · annales de biologie animale biochimie biophysique · 10
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9,13-Dicis-retinoic acid as an isomerization product of 9-cis-retinoic acid.
1997 · J O Sass, G Tzimas, et al. · PubMed · 7
Vitamin A teratogenicity and risk assessment in the macaque retinoid model
2001 · Georg Tzimas, Heinz Nau · Reproductive Toxicology · 4
Spectrophotometric determination of lipase activity in the presence of increased triolein concentration.
1992 · P L Arzoglou, A Tavridou, et al. · PubMed · 4
Proximate retinoid teratogens.
1994 · Georg Tzimas, Jörn Oliver Sass, et al. · 3
Works count: 27
Citation count: 899
H-index: 18
I10-index: 21
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