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Pamela A. Haile

Observed names: Haile, P.A., Haile, Pamela A., P.A. Haile, PA Haile, Pamela Haile, Pamela A. Haile, Pamela A. Haile
ORCID: 0000-0003-3950-4890
Observed ORCID: 0000-0003-3950-4890
OpenAlex ID: A5015952556
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
2014 · Pratyusha Mandal, Scott B. Berger, et al. · Molecular Cell · 625
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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
2020 · Alina Mares, Afjal H. Miah, et al. · Communications Biology · 232
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The Identification and Pharmacological Characterization of 6-( tert -Butylsulfonyl)- N -(5-fluoro-1 H -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
2016 · Pamela A. Haile, Bartholomew J. Votta, et al. · Journal of Medicinal Chemistry · 126
Optimization of a Series of RIPK2 PROTACs
2021 · Afjal H. Miah, Ian E. D. Smith, et al. · Journal of Medicinal Chemistry · 77
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ d ]thiazol-5-ylamino)-6-( tert -butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases
2019 · Pamela A. Haile, Linda N. Casillas, et al. · Journal of Medicinal Chemistry · 72
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Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway
2013 · David J. Rickard, Clark A. Sehon, et al. · PLoS ONE · 56
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Enantioselective Total Synthesis of Brevetoxin A: Unified Strategy for the B, E, G, and J Subunits
2009 · Michael T. Crimmins, J. Michael Ellis, et al. · Chemistry - A European Journal · 53
Total Synthesis of Brevetoxin A
2008 · Michael T. Crimmins, J. Lucas Zuccarello, et al. · Organic Letters · 50
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
2018 · Pamela A. Haile, Linda N. Casillas, et al. · ACS Medicinal Chemistry Letters · 37
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
2019 · Curt D. Haffner, Adam K. Charnley, et al. · ACS Medicinal Chemistry Letters · 29
Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway
2014 · David J. Rickard, Clark A. Sehon, et al. · PLoS ONE · 23
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Silylene oxonium ylides: di-tert-butylsilylene insertion into C–O bonds
2009 · Laura E. Bourque, Pamela A. Haile, et al. · Tetrahedron · 20
Silylene-Mediated Ring Contraction of Homoallylic Ethers To Form Allylic Silanes
2009 · Laura E. Bourque, Pamela A. Haile, et al. · The Journal of Organic Chemistry · 13
To Market, to Market—2018: Small Molecules
2019 · Erika Araujo, Marie-Gabrielle Braun, et al. · Medicinal chemistry reviews · 11
OR3-001 – RIP2 kinase is activated in Blau Syndrome and IBD
2013 · KP Foley, B Desai, et al. · Pediatric Rheumatology · 10
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CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood
2011 · Gren Z. Wang, Pamela A. Haile, et al. · Bioorganic & Medicinal Chemistry Letters · 8
Ion−Molecule Chemistry of BF3 in Clusters: Mass Spectrometric and ab Initio Computational Study of BnF3n-1+
1998 · David A. Hales, Pamela A. Haile, et al. · The Journal of Physical Chemistry A · 6
Ion−Molecule Chemistry within Boron Tribromide Clusters: Experiment and Theory
2007 · David A. Hales, Kathryn E. Kautzman, et al. · The Journal of Physical Chemistry A · 5
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
2020 · Pamela A. Haile, Linda N. Casillas, et al. · ACS Medicinal Chemistry Letters · 4
Use of novel small molecule inhibitors to investigate the role of endogenous RIP2 kinase activity in modulating NOD2/RIP2-dependent cytokine signaling (172.4)
2012 · Biva Desai, Pamela Haile, et al. · The Journal of Immunology · 2
Synthesis of13C,2H3-salmeterol: an analytical internal standard for pharmacokinetic studies
2000 · Thomas E. Goodwin, Xiang Zhou, et al. · Journal of Labelled Compounds and Radiopharmaceuticals · 2
Total Synthesis of Brevetoxin A
2020 · Emmitte, Kyle A., Parrish, Jonathan D., et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
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Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics
2020 · Mukesh K. Mahajan, Elizabeth J. Rivera, et al. · Journal of Pharmaceutical Sciences
RIP2 Kinase Catalytic Domain complex with N(4,5dimethyl1Hpyrazol3yl)7methoxy6(2methylpropane2sulfonyl)quinolin4amine
2018 · M.A. Convery, P.A. Haile · Worldwide Protein Data Bank
CCDC 1474873: Experimental Crystal Structure Determination
2016 · Haile, Pamela A., Votta, Bartholomew J., et al. · The Cambridge Structural Database
Works count: 32
Citation count: 1,461
H-index: 13
I10-index: 15
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