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Bruce J. Melancon

Observed names: B J Melancon, B.J. Melancon, Bruce J Melancon, Bruce James Melancon, Bruce Melancon, Melancon, Bruce, Melancon, Bruce J.
Observed institutions: University of Notre Dame, Louisiana State University, Johns Hopkins University, Vanderbilt University, AfaSci (United States), Vanderbilt University Medical Center
ORCID: 0000-0002-1958-0071
Observed ORCID: 0000-0002-1958-0071
OpenAlex ID: A5021719850
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
2010 · Curtis A Thorne, Alison J Hanson, et al. · Nature Chemical Biology · 484
Structural insights into HDAC6 tubulin deacetylation and its selective inhibition
2016 · Yasuyuki Miyake, Jeremy J Keusch, et al. · Nature Chemical Biology · 305
Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery
2011 · Bruce J. Melancon, Corey R. Hopkins, et al. · Journal of Medicinal Chemistry · 226
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
2014 · Michael Bubser, Thomas M. Bridges, et al. · ACS Chemical Neuroscience · 154
Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100
2014 · Nellie E Byun, Michael Grannan, et al. · Neuropsychopharmacology · 122
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Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease
2013 · Bruce J. Melancon, James C. Tarr, et al. · Drug Discovery Today · 119
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model
2015 · A Ghoshal, J M Rook, et al. · Neuropsychopharmacology · 107
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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease
2011 · Zixiu Xiang, Analisa D. Thompson, et al. · ACS Chemical Neuroscience · 98
A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors
2011 · Tasia M. Pyburn, Barbara A. Bensing, et al. · PLoS Pathogens · 84
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Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7
2014 · Nidhi Jalan-Sakrikar, Julie R. Field, et al. · ACS Chemical Neuroscience · 69
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Chromophore Formation in Resorcinarene Solutions and the Visual Detection of Mono- and Oligosaccharides
2002 · Ming He, Rolanda J. Johnson, et al. · Journal of the American Chemical Society · 65
Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia
2016 · Michael R. Wood, Meredith J. Noetzel, et al. · ACS Medicinal Chemistry Letters · 53
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354
2014 · Wandong Wen, Summer E. Young, et al. · Bioorganic & Medicinal Chemistry Letters · 43
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
2016 · Michael R. Wood, Meredith J. Noetzel, et al. · Bioorganic & Medicinal Chemistry Letters · 41
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
2012 · Uyen Le, Bruce J. Melancon, et al. · Bioorganic & Medicinal Chemistry Letters · 41
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071
2011 · Evan P. Lebois, Gregory J. Digby, et al. · Bioorganic & Medicinal Chemistry Letters · 37
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule
2013 · Michael S. Poslusney, Bruce J. Melancon, et al. · Bioorganic & Medicinal Chemistry Letters · 32
Progress toward the Total Synthesis of Lucentamycin A: Total Synthesis and Biological Evaluation of 8-epi-Lucentamycin A
2009 · R. Nathan Daniels, Bruce J. Melancon, et al. · The Journal of Organic Chemistry · 28
2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease
2019 · Jessica Davidson, Elizabeth Molitor, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 24
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
2017 · Bruce J. Melancon, Michael R. Wood, et al. · Bioorganic & Medicinal Chemistry Letters · 24
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core
2016 · Michael R. Wood, Meredith J. Noetzel, et al. · Bioorganic & Medicinal Chemistry Letters · 23
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule
2012 · Bruce J. Melancon, Michael S. Poslusney, et al. · Bioorganic & Medicinal Chemistry Letters · 23
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides
2017 · James C. Tarr, Michael R. Wood, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Competitive Cationic Pathways and the Asymmetric Synthesis of Aryl-Substituted Cyclopropanes
2007 · Bruce J. Melancon, Nicholas R. Perl, et al. · Organic Letters · 22
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization
2024 · Alexa Strauss, Alberto J. Gonzalez-Hernandez, et al. · Nature Communications · 21
Works count: 114
Citation count: 2,441
H-index: 22
I10-index: 31
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