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Francesca Blasco

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
2013 · Pascal Furet, Vito Guagnano, et al. · Bioorganic & Medicinal Chemistry Letters · 483
Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research
2014 · Tove Tuntland, Brian Ethell, et al. · Frontiers in Pharmacology · 238
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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
2017 · Ujjini H. Manjunatha, Sumiti Vinayak, et al. · Nature · 207
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Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
2013 · Srinivasa P. S. Rao, Suresh B. Lakshminarayana, et al. · Science Translational Medicine · 147
Direct inhibitors of InhA are active against Mycobacterium tuberculosis
2015 · Ujjini H. Manjunatha, Srinivasa P. S. Rao, et al. · Science Translational Medicine · 136
Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805
2010 · Fabienne Baffert, Catherine H. Régnier, et al. · Molecular Cancer Therapeutics · 120
Discovery of Dengue Virus NS4B Inhibitors
2015 · Qing-Yin Wang, Hongping Dong, et al. · Journal of Virology · 105
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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
2021 · Stephanie A. Moquin, Oliver Simon, et al. · Science Translational Medicine · 103
Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir
2013 · Yen-Liang Chen, Nahdiyah Abdul Ghafar, et al. · Journal of Virology · 82
Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors
2015 · Bin Zou, Wai Ling Chan, et al. · ACS Medicinal Chemistry Letters · 73
The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588
2013 · Paul W. Manley, Francesca Blasco, et al. · Bioorganic & Medicinal Chemistry · 52
Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580
2014 · Yilong Fu, Andy Yip, et al. · Antiviral Research · 43
Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
2010 · Carole Pissot-Soldermann, Marc Gerspacher, et al. · Bioorganic & Medicinal Chemistry Letters · 41
Optimised method to estimate octanol water distribution coefficient (logD) in a high throughput format
2016 · Ying Wei (Ivan) Low, Francesca Blasco, et al. · European Journal of Pharmaceutical Sciences · 40
Trifluoromethyl vs. methyl ability to direct enantioselection in microbial reduction of carbonyl substrates.
1998 · Alberto Arnone, Rosanna Bernardi, et al. · Tetrahedron · 39
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit
2009 · Katrin Groebke Zbinden, Lilli Anselm, et al. · European Journal of Medicinal Chemistry · 37
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration
2007 · Jens-Uwe Peters, Thomas Lübbers, et al. · Bioorganic & Medicinal Chemistry Letters · 30
A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′- C -Methylguanosine for the Treatment of Dengue Virus Infection
2020 · Ratna Karuna, Fumiaki Yokokawa, et al. · Antimicrobial Agents and Chemotherapy · 29
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Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
2009 · Guido Achermann, Theresa M. Ballard, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis
2014 · Suresh B. Lakshminarayana, Helena I. M. Boshoff, et al. · PLoS ONE · 25
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2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
2010 · Marc Gerspacher, Pascal Furet, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors
2015 · Robin A. Fairhurst, Marc Gerspacher, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
2014 · Suresh B. Lakshminarayana, Céline Freymond, et al. · Antimicrobial Agents and Chemotherapy · 17
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Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]
2013 · Pascal Furet, Vito Guagnano, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation
2007 · Jens-Uwe Peters, Thomas Lübbers, et al. · Bioorganic & Medicinal Chemistry Letters · 13
Works count: 41
Citation count: 2,173
H-index: 21
I10-index: 26
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