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Chafiq Hamdouchi

Observed names: C. HAMDOUCHI, C. Hamdouchi, Hamdouchi, Chafiq
Observed institutions: Florida State University, Centre National de la Recherche Scientifique, Eli Lilly (United States), Universidad de Alcalá, Riley Hospital for Children, Eli Lilly (Spain), Indiana University Indianapolis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis, Universidad Autónoma de Madrid
ORCID: 0000-0001-7683-2012
Observed ORCIDs: 0000-0001-7683-2012, 0000-0002-9625-6566
OpenAlex ID: A5025992004
2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity
1998 · Chafiq Hamdouchi, Jesús de Blas, et al. · Journal of Medicinal Chemistry · 280
3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism
2007 · Donald R. Gehlert, Andrea Cippitelli, et al. · Journal of Neuroscience · 239
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Delayed Functional Expression of Neuronal Chemokine Receptors Following Focal Nerve Demyelination in the Rat: A Mechanism for the Development of Chronic Sensitization of Peripheral Nociceptors
2007 · Sonia Bhangoo, Dongjun Ren, et al. · Molecular Pain · 170
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Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases
2005 · Chafiq Hamdouchi, Boyu Zhong, et al. · Bioorganic & Medicinal Chemistry Letters · 90
Structural basis for GPR40 allosteric agonism and incretin stimulation
2018 · Joseph D. Ho, Betty Chau, et al. · Nature Communications · 84
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On the reaction of chiral sulfinimines with sulfur ylides: a novel route to the asymmetric aziridination
1995 · JoséL García Ruano, Inmaculada Fernández, et al. · Tetrahedron Letters · 67
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)
2016 · Chafiq Hamdouchi, Steven D. Kahl, et al. · Journal of Medicinal Chemistry · 64
A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines
1999 · Juan A. Vega, Juan J. Vaquero, et al. · Tetrahedron · 61
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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond
2009 · Roberto Ciccocioppo, Donald R. Gehlert, et al. · Alcohol · 58
Chemoselective Arylsulfenylation of 2-Aminoimidazol[1,2-a]pyridines by Phenyliodine(III) Bis(trifluoroacetate) (PIFA)
1998 · Chafiq Hamdouchi · Synthesis · 47
Surface nature of Grignard reagent formation. Chiral 1-methylspiro[2.5]octylmagnesium bromide
1993 · C. Hamdouchi, M. Topolski, et al. · The Journal of Organic Chemistry · 45
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
2021 · Anita C. Bellail, Hong Ri Jin, et al. · Science Translational Medicine · 42
Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: The effect of acyl groups at 3-position
1999 · Chafiq Hamdouchi, Jesús Ezquerra, et al. · Bioorganic & Medicinal Chemistry Letters · 42
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(S,S)-bis-p-tolylsulfinylmethane and carbonyl compounds: reactivity and asymmetric induction
1991 · Guy Solladié, Françoise Colobert, et al. · Tetrahedron Letters · 41
Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses: Design, Synthesis, and Biological Evaluation
2003 · Chafiq Hamdouchi, Concha Sanchez-Martinez, et al. · Journal of Medicinal Chemistry · 39
Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation
2004 · Carlos Jaramillo, J. Eugenio de Diego, et al. · Bioorganic & Medicinal Chemistry Letters · 38
A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2-a]pyridine
1999 · Chafiq Hamdouchi, Jesús de Blas, et al. · Tetrahedron · 37
Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridines
2002 · Carlos Jaramillo, Juan Carlos Carretero, et al. · Tetrahedron Letters · 33
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus
2017 · Chafiq Hamdouchi, Pranab Maiti, et al. · Journal of Medicinal Chemistry · 32
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines
2004 · Chafiq Hamdouchi, Heather Keyser, et al. · Molecular Cancer Therapeutics · 31
The nature of electron transfer from metal surfaces to the carbon-halogen bond
1993 · H. M. Walborsky, C. Hamdouchi · Journal of the American Chemical Society · 30
New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types
2024 · Silpa Gampala, Hye-ran Moon, et al. · Pharmacological Research · 29
A new approach to the asymmetric cyclopropanation via a chiral sulfinyl group
1992 · Chafiq Hamdouchi · Tetrahedron Letters · 27
Asymmetric synthesis of the C-1-C-8 fragment of leukotriene B4 and C-11-C-20 fragments of leukotriene B4 and 12(S)-hydroxy-5,8,14(Z), 10(E) eicosatetraenoic acid
1991 · Guy Solladié, Chafiq Hamdouchi, et al. · Tetrahedron Asymmetry · 26
A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
2016 · Yanyun Chen, Min Song, et al. · Pharmacology Research & Perspectives · 23
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Works count: 91
Citation count: 1,894
H-index: 24
I10-index: 36
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