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Trupta Purohit

Observed name: T. Purohit
ORCID: 0000-0003-0697-4140
Observed ORCID: 0000-0003-0697-4140
OpenAlex ID: A5026691889
Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin
2008 · Gary J. Fisher, Taihao Quan, et al. · American Journal Of Pathology · 483
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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
2012 · Jolanta Grembecka, Shihan He, et al. · Nature Chemical Biology · 462
Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo
2015 · Dmitry Borkin, Shihan He, et al. · Cancer Cell · 392
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Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
2019 · Szymon Klossowski, Hongzhi Miao, et al. · Journal of Clinical Investigation · 246
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Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
2012 · Aibin Shi, Marcelo J. Murai, et al. · Blood · 204
Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes
2015 · Jonathan Pollock, Dmitry Borkin, et al. · Journal of Medicinal Chemistry · 107
High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction
2014 · Shihan He, Timothy J. Senter, et al. · Journal of Medicinal Chemistry · 96
Covalent inhibition of NSD1 histone methyltransferase
2020 · Huang Huang, Christina A. Howard, et al. · Nature Chemical Biology · 85
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)
2016 · Dmitry Borkin, Jonathan Pollock, et al. · Journal of Medicinal Chemistry · 76
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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
2021 · Shirish Shukla, Weijiang Ying, et al. · Nature Chemical Biology · 65
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Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction
2018 · Dmitry Borkin, Szymon Klossowski, et al. · Journal of Medicinal Chemistry · 63
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Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations
2020 · Hongzhi Miao, EunGi Kim, et al. · Blood · 47
Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging
2016 · Trupta Purohit, Tianyuan He, et al. · Journal of Dermatological Science · 44
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity
2021 · David S. Rogawski, Jing Deng, et al. · Nature Communications · 42
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The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV
2014 · Marcelo J. Murai, Jonathan Pollock, et al. · Blood · 41
Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations
2024 · Hongzhi Miao, Dong Chen, et al. · Leukemia · 24
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Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts
2017 · Trupta Purohit, Zhaoping Qin, et al. · PLoS ONE · 17
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EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma
2021 · Jennifer A. Jiménez, April A. Apfelbaum, et al. · Molecular Cancer Research · 14
Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules
2017 · Wiktoria Jedwabny, Szymon Kłossowski, et al. · MedChemComm · 11
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Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction
2020 · Paulina Fortuna, Brian M. Linhares, et al. · European Journal of Medicinal Chemistry · 10
Discovery and preclinical activity of the menin-KMT2A inhibitor ziftomenib in acute leukemia models
2026 · Hongzhi Miao, Tao Wu, et al. · Blood · 6
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Abstract 5077: A novel small molecule menin-MLL inhibitor for potential treatment of MLL-rearranged leukemias
2017 · Tao Wu, Linda Kessler, et al. · Cancer Research · 6
Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors
2024 · Guang Huang, Rhiannon Stevens, et al. · Journal of Medicinal Chemistry · 5
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Combination of Menin and IDH Mutant Inhibition in Acute Myeloid Leukemia
2022 · James J. Yoon, Hongzhi Miao, et al. · Blood · 2
Abstract 50: Small molecule Ring1B-Bmi1 inhibitor attenuates PRC1 E3 ligase activity and targets leukemia stem cells self-renewal
2017 · Shirish Shukla, Felicia Gray, et al. · Clinical Cancer Research · 2
Works count: 58
Citation count: 2,557
H-index: 17
I10-index: 20
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