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Alexander Olegovich Shpakov

Observed names: A O SHPAKOV, A O Shpakov, A Shpakov, A. O Shpakov, A. O. Shpakov, A. Shpakov, A.O SHPAKOV, A.O Shpakov, A.O. Shpakov, ALEXANDER SHPAKOV, Alexander O Shpakov, Alexander O. Shpakov, Alexander Shpakov, Alexandr Shpakov, Shpakov, A.O., Shpakov, Alexander O., А О Шпаков, А Шпаков, А. О. Шпаков, А.О. Шпаков, Шпаков, А.О.
Observed institutions: Russian Academy of Sciences, Institute of Evolutionary Physiology and Biochemistry, St Petersburg University, St.Petersburg V.M.Bekhterev Psychoneurological Research Institute, Chelyabinsk State Medical Academy, Federal Almazov North-West Medical Research Centre, Federal Research Centre of Nutrition and Biotechnology, Institute of Macromolecular Compounds, Institute of Experimental Medicine, University of Arkansas for Medical Sciences
ORCID: 0000-0002-4293-3162
Observed ORCID: 0000-0002-4293-3162
OpenAlex ID: A5029237066
Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases
2015 · Alexander O Shpakov, Kira V Derkach, et al. · Future Science OA · 91
The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents
2018 · Irina V. Romanova, Kira V. Derkach, et al. · Neurochemical Research · 78
Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms
2021 · Alexander O. Shpakov · Pharmaceuticals · 74
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The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes
2015 · Kira V. Derkach, Vera M. Bondareva, et al. · International Journal of Endocrinology · 72
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The Peptides Mimicking the Third Intracellular Loop of 5-Hydroxytryptamine Receptors of the Types 1B and 6 Selectively Activate G Proteins and Receptor-Specifically Inhibit Serotonin Signaling via the Adenylyl Cyclase System
2010 · Alexander O. Shpakov, Elena A. Shpakova, et al. · International Journal of Peptide Research and Therapeutics · 63
The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect
2019 · Kira Derkach, Irina Zakharova, et al. · PLoS ONE · 59
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Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands
2023 · Alexander Shpakov · International Journal of Molecular Sciences · 55
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Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium
2023 · Alexander O. Shpakov, Inna I. Zorina, et al. · International Journal of Molecular Sciences · 54
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The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats
2015 · K. Derkach, I. Bogush, et al. · Hormone and Metabolic Research · 54
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Chapter 4 Signaling Systems of Lower Eukaryotes and Their Evolution
2008 · Alexander O. Shpakov, Marianna N. Pertseva · International review of cytology · 51
The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis
2021 · Andrey A. Bakhtyukov, Kira V. Derkach, et al. · International Journal of Molecular Sciences · 48
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A novel view on the mechanisms of action of insulin and other insulin superfamily peptides: involvement of adenylyl cyclase signaling system
2003 · M.N Pertseva, A.O Shpakov, et al. · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · 45
Functional defects in adenylyl cyclase signaling mechanisms of insulin and relaxin in skeletal muscles of rat with streptozotocin type 1 diabetes
2006 · Alexander Shpakov, Ludmila Kuznetsova, et al. · Open Life Sciences · 40
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Studies of the molecular mechanisms of action of relaxin on the adenylyl cyclase signaling system using synthetic peptides derived from the LGR7 relaxin receptor
2007 · A. O. Shpakov, I. A. Gur’yanov, et al. · Neuroscience and Behavioral Physiology · 39
A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates11Abbreviations: PKC, protein kinase C (α, λ, ε, ϕ, ζ, its isoforms); AC, adenylyl cyclase (EC 4.6.1.1); AC I, II, etc. (isoforms of AC); ACSM, adenylyl cyclase signaling mechanism; DAG, diacylglycerol; PE, phorbol esters; PMA, phorbol 12-myristate 13-acetate; PI3-K, phosphatidylinositol 3-kinase; Gs-protein, stimulatory GTP-binding protein; Gi-protein, inhibitory GTP-binding protein; α, β, γ, the subunits of G-proteins; IGF-I, insulin-like growth factor-I; PT, pertussis toxin; ChT, cholera toxin; Gpp[NH]p, 5′-guanylylimidodiphosphate; DTT, dithiothreitol; and cAMP, adenosine 3′,5′-cyclic monophosphate.
2001 · Svetlana A. Plesneva, Alexander O. Shpakov, et al. · Biochemical Pharmacology · 38
The effect of metformin treatment on the basal and gonadotropin‐stimulated steroidogenesis in male rats with type 2 diabetes mellitus
2020 · Kira V. Derkach, Andrey A. Bakhtyukov, et al. · Andrologia · 36
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Involvement of the adenylyl cyclase signaling system in the action of insulin and mollusk insulin-like peptide
1995 · M.N. Pertseva, S.A. Plesneva, et al. · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · 36
The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities
2019 · Irina O. Zakharova, Tatiana V. Sokolova, et al. · International Journal of Molecular Sciences · 35
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Conservatism of the Insulin Signaling System in Evolution of Invertebrate and Vertebrate Animals
2002 · M. N. Pertseva, A. O. Shpakov · Journal of Evolutionary Biochemistry and Physiology · 35
On the tyrosine kinase mechanism of the novel effect of insulin and insulinlike growth factor I
1996 · Marianna N. Pertseva, Svetlana A. Plesneva, et al. · Biochemical Pharmacology · 35
Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes
2011 · Alexander Shpakov, Oksana Chistyakova, et al. · Open Life Sciences · 34
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Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats
2020 · Andrey A. Bakhtyukov, Kira V. Derkach, et al. · International Journal of Molecular Sciences · 30
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Hormonal Signaling Systems of the Brain in Diabetes Mellitus
2011 · Alexander Shpakov, Oksana Chistyakova, et al. · InTech eBooks · 28
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In vitro and in vivo studies of functional activity of new low molecular weight agonists of the luteinizing hormone receptor
2016 · K. V. Derkach, D. V. Dar’in, et al. · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · 27
The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus
2013 · Alexander O. Shpakov, Kira V. Derkach · Journal of Signal Transduction · 26
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Works count: 560
Citation count: 3,089
H-index: 25
I10-index: 87
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