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Wonsuk Chang

An orally available non-nucleotide STING agonist with antitumor activity
2020 · Bo-Sheng Pan, Samanthi A. Perera, et al. · Science · 696
Discovery of a β- d -2′-Deoxy-2′-α-fluoro-2′-β- C -methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
2010 · Michael J. Sofia, Donghui Bao, et al. · Journal of Medicinal Chemistry · 630
Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977
2010 · Eisuke Murakami, Tatiana Tolstykh, et al. · Journal of Biological Chemistry · 295
Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase
2011 · Michael J. Sofia, Wonsuk Chang, et al. · Journal of Medicinal Chemistry · 276
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
2022 · Wonsuk Chang, Michael D. Altman, et al. · Journal of Medicinal Chemistry · 159
A kinase-cGAS cascade to synthesize a therapeutic STING activator
2022 · John A. McIntosh, Zhijian Liu, et al. · Nature · 143
Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells
2008 · V. Badireenath Konkimalla, Martina Blunder, et al. · Nitric Oxide · 95
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
2019 · Whitney L. Petrilli, Gregory C. Adam, et al. · Cell chemical biology · 89
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Malaria-Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives
2007 · Gary H. Posner, Ik-Hyeon Paik, et al. · Journal of Medicinal Chemistry · 69
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
2012 · Wonsuk Chang, Ralph T. Mosley, et al. · Bioorganic & Medicinal Chemistry Letters · 67
Biological Mechanisms of Action of Novel C-10 Non-Acetal Trioxane Dimers in Prostate Cancer Cell Lines
2006 · Adebusola A. Alagbala, Andrew J. McRiner, et al. · Journal of Medicinal Chemistry · 66
2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
2010 · P. Ganapati Reddy, Donghui Bao, et al. · Bioorganic & Medicinal Chemistry Letters · 59
A Synthesis of l -Vancosamine Derivatives from Non-Carbohydrate Precursors by a Short Sequence Based on the Marshall, McDonald, and Du Bois Reactions
2003 · Kathlyn A. Parker, Wonsuk Chang · Organic Letters · 59
Regioselectivity of Rhodium Nitrene Insertion. Syntheses of Protected Glycals of l -Daunosamine, d -Saccharosamine, and l -Ristosamine
2005 · Kathlyn A. Parker, Wonsuk Chang · Organic Letters · 58
Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives
2014 · Ramesh Kakarla, Jian Liu, et al. · Journal of Medicinal Chemistry · 54
Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection
2010 · Wonsuk Chang, Donghui Bao, et al. · ACS Medicinal Chemistry Letters · 53
Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives
2008 · Gary H. Posner, Wonsuk Chang, et al. · Journal of Medicinal Chemistry · 53
Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661
2011 · Phillip A. Furman, Eisuke Murakami, et al. · Antiviral Research · 46
Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection
2007 · Won-Suk Chang, Hao Shang, et al. · The Analyst · 46
Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β- d -2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
2011 · Angela M. Lam, Christine Espiritu, et al. · Antimicrobial Agents and Chemotherapy · 37
Malaria-Infected Mice Live until at Least Day 30 after a New Monomeric Trioxane Combined with Mefloquine Are Administered Together in a Single Low Oral Dose
2009 · Lauren E. Woodard, Wonsuk Chang, et al. · Journal of Medicinal Chemistry · 31
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
2024 · Valerie W. Shurtleff, Mark E. Layton, et al. · Journal of Medicinal Chemistry · 29
Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938
2012 · Congrong Niu, Tatiana Tolstykh, et al. · Antimicrobial Agents and Chemotherapy · 23
Templated synthesis of gold–iron alloy nanoparticles using pulsed laser deposition
2006 · Won-Suk Chang, Jin-Won Park, et al. · Nanotechnology · 14
An aspartic protease analogue: intermolecular catalysis of peptide hydrolysis by carboxyl groups
2001 · Sezu Oh, Wonsuk Chang, et al. · Bioorganic & Medicinal Chemistry Letters · 13
Works count: 42
Citation count: 3,217
H-index: 23
I10-index: 27
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