Author

Mimi L. C. Quan

Observed names: M. L. C. QUAN, M. L. QUAN, M. Quan, M.L. Quan, Mimi L Quan, Mimi L. Quan, Mimi Quan, Quan, Mimi L.

Institution: Bristol-Myers Squibb (United States)

Observed institutions: DuPont (United States), University of California, Los Angeles, Bristol-Myers Squibb (United States)

ORCID: 0000-0001-5866-0114

Observed ORCID: 0000-0001-5866-0114

OpenAlex ID: A5030883249

Constrictive binding of large guests by a hemicarcerand containing four portals

1991 · Mimi L. C. Quan, Donald J. Cram · Journal of the American Chemical Society · 199

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

2004 · Mimi L. Quan, Patrick Y. S. Lam, et al. · Journal of Medicinal Chemistry · 192

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

2001 · Donald J. P. Pinto, Michael J. Orwat, et al. · Journal of Medicinal Chemistry · 174

Inhibition of Factor XIa as a New Approach to Anticoagulation

2010 · William A. Schumacher, Joseph M. Luettgen, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 96

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Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1

1999 · Mimi L. Quan, Ann Y. Liauw, et al. · Journal of Medicinal Chemistry · 82

Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors

2014 · Mimi L. Quan, Pancras C. Wong, et al. · Journal of Medicinal Chemistry · 80

Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 2

1999 · Mimi L. Quan, Christopher D. Ellis, et al. · Journal of Medicinal Chemistry · 77

Nonpeptide Factor Xa Inhibitors: I. Studies with SF303 and SK549, a New Class of Potent Antithrombotics

2000 · Pancras C. Wong, Mimi L. Quan, et al. · Journal of Pharmacology and Experimental Therapeutics · 73

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

2006 · Donald J.P. Pinto, Michael J. Orwat, et al. · Bioorganic & Medicinal Chemistry Letters · 65

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

2017 · Donald J. P. Pinto, Michael J. Orwat, et al. · Journal of Medicinal Chemistry · 58

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

2007 · Donglu Zhang, Nirmala Raghavan, et al. · Drug Metabolism and Disposition · 58

Factor XIa Inhibitors as New Anticoagulants

2018 · Mimi L. Quan, Donald J. P. Pinto, et al. · Journal of Medicinal Chemistry · 55

Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

2015 · Donald J.P. Pinto, Joanne M. Smallheer, et al. · Bioorganic & Medicinal Chemistry Letters · 45

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

2017 · James R. Corte, Tianan Fang, et al. · Journal of Medicinal Chemistry · 42

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Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity

2014 · Jon J. Hangeland, Todd J. Friends, et al. · Journal of Medicinal Chemistry · 42

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

2001 · John M. Fevig, Donald J. Pinto, et al. · Bioorganic & Medicinal Chemistry Letters · 40

In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa

2015 · Pancras C. Wong, Mimi L. Quan, et al. · Journal of Thrombosis and Thrombolysis · 39

Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors

1998 · John V. Duncia, Joseph B. Santella, et al. · Bioorganic & Medicinal Chemistry Letters · 39

The Design and Synthesis of Noncovalent Factor Xa Inhibitors

2001 · M. Quan, R. Wexler · Current Topics in Medicinal Chemistry · 37

Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits

2007 · Pancras C. Wong, Earl J. Crain, et al. · Journal of Thrombosis and Thrombolysis · 34

Nonbenzamidine tetrazole derivatives as factor Xa inhibitors

2003 · Mimi L Quan, Christopher D Ellis, et al. · Bioorganic & Medicinal Chemistry Letters · 34

Novel phenylalanine derived diamides as Factor XIa inhibitors

2015 · Leon M. Smith, Michael J. Orwat, et al. · Bioorganic & Medicinal Chemistry Letters · 31

Nonpeptide Factor Xa Inhibitors II. Antithrombotic Evaluation in a Rabbit Model of Electrically Induced Carotid Artery Thrombosis

2000 · Pancras C. Wong, Earl J. Crain, et al. · Journal of Pharmacology and Experimental Therapeutics · 30

Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties

2006 · Donald J.P. Pinto, Robert A. Galemmo, et al. · Bioorganic & Medicinal Chemistry Letters · 29

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors

1997 · M.L. Quan, J.R. Pruitt, et al. · Bioorganic & Medicinal Chemistry Letters · 29

Works count: 60

Citation count: 2,103

H-index: 27

I10-index: 46