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Remko A. Bakker

Observed names: Bakker, R.A., R. A. Bakker, R.A. Bakker, Remko A Bakker, Remko Bakker, Remko A. Bakker
Observed institutions: Boehringer Ingelheim (Germany), Utrecht University, Leiden University Medical Center, University of Florida, University of Regensburg, Naresuan University, Freie Universität Berlin, Vrije Universiteit Amsterdam, Osaka University of Pharmaceutical Sciences, The University of Osaka
ORCID: 0000-0003-1449-2862
Observed ORCID: 0000-0003-1449-2862
OpenAlex ID: A5031664049
Empagliflozin, a novel selective sodium glucose cotransporter‐2 (SGLT‐2) inhibitor: characterisation and comparison with other SGLT‐2 inhibitors
2011 · R. Grempler, L. Thomas, et al. · Diabetes Obesity and Metabolism · 605
The histamine H3 receptor: from gene cloning to H3 receptor drugs
2005 · Rob Leurs, Remko A. Bakker, et al. · Nature Reviews Drug Discovery · 485
Evaluation of Histamine H1-, H2-, and H3-Receptor Ligands at the Human Histamine H4 Receptor: Identification of 4-Methylhistamine as the First Potent and Selective H4 Receptor Agonist
2005 · Herman D. Lim, Richard M. van Rijn, et al. · Journal of Pharmacology and Experimental Therapeutics · 280
Histamine H1-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gαq/11-Subunits in Constitutive and Agonist-Mediated Signaling
2001 · Remko A. Bakker, Stefan B. J. Schoonus, et al. · Molecular Pharmacology · 256
Constitutive Signaling of the Human Cytomegalovirus-encoded Chemokine Receptor US28
2001 · Paola Casarosa, Remko A. Bakker, et al. · Journal of Biological Chemistry · 243
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Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity
2006 · Martine J. Smit, Henry F. Vischer, et al. · The Annual Review of Pharmacology and Toxicology · 188
Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists
2000 · Remko A Bakker, Kerstin Wieland, et al. · European Journal of Pharmacology · 164
Characterization of the Histamine H4Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives
2006 · Rogier A. Smits, Herman D. Lim, et al. · Journal of Medicinal Chemistry · 136
Molecular aspects of the histamine H3 receptor
2007 · Gerold Bongers, Remko A. Bakker, et al. · Biochemical Pharmacology · 124
Synthesis and structure–activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists
2004 · Nalan Terzioglu, Richard M. van Rijn, et al. · Bioorganic & Medicinal Chemistry Letters · 113
Molecular Cloning and Pharmacological Characterization of a Molluscan Octopamine Receptor
1997 · Cindy C. Gerhardt, Remko A. Bakker, et al. · Molecular Pharmacology · 100
Histamine Receptors: Specific Ligands, Receptor Biochemistry, and Signal Transduction
2002 · Remko A. Bakker, Hendrik Timmerman, et al. · CRC Press eBooks · 95
Linking agonist binding to histamine H1 receptor activation
2005 · Aldo Jongejan, Martijn Bruysters, et al. · Nature Chemical Biology · 91
In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy
2021 · Kolja Becker, Holger Klein, et al. · Scientific Reports · 86
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Domain Swapping in the Human Histamine H1 Receptor
2004 · Remko A. Bakker, Guido Dees, et al. · Journal of Pharmacology and Experimental Therapeutics · 78
Discovery of S-(2-Guanidylethyl)-isothiourea (VUF 8430) as a Potent Nonimidazole Histamine H4 Receptor Agonist
2006 · Herman D. Lim, Rogier A. Smits, et al. · Journal of Medicinal Chemistry · 74
The Akt/GSK‐3β axis as a new signaling pathway of the histamine H3receptor
2007 · Gerold Bongers, Tina Sallmen, et al. · Journal of Neurochemistry · 69
Oligomerization of Recombinant and Endogenously Expressed Human Histamine H4 Receptors
2006 · Richard M. van Rijn, Paul L. Chazot, et al. · Molecular Pharmacology · 68
Discovery of Naturally Occurring Splice Variants of the Rat Histamine H3 Receptor That Act as Dominant-Negative Isoforms
2006 · Remko A. Bakker, Adrian Flores Lozada, et al. · Molecular Pharmacology · 68
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor
2008 · Richard M. van Rijn, André van Marle, et al. · Biochemical Journal · 65
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Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure
2016 · Gisela Schnapp, Thomas Klein, et al. · Journal of Medicinal Chemistry · 64
Identification of 4-(1H-Imidazol-4(5)-ylmethyl)pyridine (Immethridine) as a Novel, Potent, and Highly Selective Histamine H3Receptor Agonist
2004 · Ruengwit Kitbunnadaj, Obbe P. Zuiderveld, et al. · Journal of Medicinal Chemistry · 62
A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation
2010 · Kamonchanok Sansuk, Xavier Deupi, et al. · Molecular Pharmacology · 61
Molecular Determinants of Ligand Binding to H4R Species Variants
2010 · Herman D. Lim, Chris de Graaf, et al. · Molecular Pharmacology · 59
A Selective Human H4-Receptor Agonist: (−)-2-Cyano-1-methyl-3-{(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine
2003 · Takeshi Hashimoto, Shinya Harusawa, et al. · Journal of Medicinal Chemistry · 58
Works count: 85
Citation count: 4,770
H-index: 37
I10-index: 58
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