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Ian N. Foltz
Observed names:
Foltz, Ian Nevin,
I N Foltz,
Ian Foltz,
Ian N. Foltz
Institutions:
Amgen (United States),
Amgen (Canada)
Observed institutions:
AstraZeneca (United Kingdom),
Amgen (United States),
University of British Columbia,
Vancouver Hospital and Health Sciences Centre,
Electronic Arts (Canada),
Amgen (Canada)
show all 6
OpenAlex ID:
A5034901985
Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody
2015
·
Ross Stewart
, Michelle Morrow
, et al.
·
Cancer Immunology Research
·
410
Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects
2010
·
Kannan Gunasekaran
, Martin Pentony
, et al.
·
Journal of Biological Chemistry
·
282
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
2018
·
Elizabeth A. Killion
, Jinghong Wang
, et al.
·
Science Translational Medicine
·
237
Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
2012
·
Ian N. Foltz
, Sylvia Hu
, et al.
·
Science Translational Medicine
·
208
Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway
1997
·
Ian N. Foltz
, John C. Lee
, et al.
·
Journal of Biological Chemistry
·
167
Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity
2014
·
Jonathan D. Graves
, Jennifer J. Kordich
, et al.
·
Cancer Cell
·
157
PDF
Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2
2018
·
Athena Sudom
, Santosh Talreja
, et al.
·
Journal of Biological Chemistry
·
145
PDF
Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT
2012
·
Sandra L. Ross
, Lynn Tran
, et al.
·
Cell Metabolism
·
145
PDF
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
2021
·
Daniel C. Ellwanger
, Shoutang Wang
, et al.
·
Proceedings of the National Academy of Sciences
·
143
TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function
2018
·
Qingwen Cheng
, Jean Danao
, et al.
·
Journal of Biological Chemistry
·
129
PDF
Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types
2010
·
Paula J. Kaplan-Lefko
, Jonathan D. Graves
, et al.
·
Cancer Biology & Therapy
·
125
PDF
A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates
2013
·
Keegan S. Cooke
, Beth Hinkle
, et al.
·
Blood
·
113
AMG 595, an Anti-EGFRvIII Antibody–Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma
2015
·
Kevin J. Hamblett
, Carl J. Kozlosky
, et al.
·
Molecular Cancer Therapeutics
·
101
Evolution and Emergence of Therapeutic Monoclonal Antibodies
2013
·
Ian N. Foltz
, Margaret Karow
, et al.
·
Circulation
·
99
PDF
Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli
1998
·
Ian N. Foltz
, Robert E. Gerl
, et al.
·
Journal of Biological Chemistry
·
97
A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
2012
·
C Eberlein
, J Kendrew
, et al.
·
Oncogene
·
87
The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors
1997
·
R A Salmon
, I N Foltz
, et al.
·
The Journal of Immunology
·
84
A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism
2015
·
Zhi Liu
, Esther C. Leng
, et al.
·
Journal of Biological Chemistry
·
75
Asymmetrical Fc Engineering Greatly Enhances Antibody-dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies
2013
·
Zhi Liu
, Kannan Gunasekaran
, et al.
·
Journal of Biological Chemistry
·
75
Activation of the Stress-Activated Protein Kinases by Multiple Hematopoietic Growth Factors With the Exception of Interleukin-4
1997
·
Ian N. Foltz
, John W. Schrader
·
Blood
·
71
MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
2012
·
David W. Jenkins
, Sarah Ross
, et al.
·
Molecular Cancer Therapeutics
·
51
Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival
1999
·
Michael P. Scheid
, Ian N. Foltz
, et al.
·
Blood
·
46
Discovery and bio‐optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform
2016
·
Ian N. Foltz
, Kannan Gunasekaran
, et al.
·
Immunological Reviews
·
37
An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding
2011
·
Jane Kendrew
, Cath Eberlein
, et al.
·
Molecular Cancer Therapeutics
·
33
Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab
2019
·
Shea Jassem
, Wei Wang
, et al.
·
Pharmaceutical Research
·
17
PDF
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Works count:
53
Citation count:
3,192
H-index:
24
I10-index:
28
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