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Yumiko Hirokawa

Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?
2019 · Mayur Garg, Simon G Royce, et al. · Gut · 211
Wnt Signalling Pathway Parameters for Mammalian Cells
2012 · Chin Wee Tan, Bruce S. Gardiner, et al. · PLoS ONE · 127
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Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
2023 · Zilu Wang, Matteo Burigotto, et al. · Cancer Discovery · 106
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A Clue to the Therapy of Neurofibromatosis Type 2
2004 · Yumiko Hirokawa, Anjali Tikoo, et al. · The Cancer Journal · 100
Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance
2005 · Yumiko Hirokawa, Melissa Arnold, et al. · Cancer Biology & Therapy · 81
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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration
2014 · Toby J. Phesse, Michael Buchert, et al. · Science Signaling · 76
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Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Journal of Medicinal Chemistry · 74
The K252a Derivatives, Inhibitors for the PAK/MLK Kinase Family, Selectively Block the Growth of HAS Transformants
2002 · Thao V Nheu, Hong He, et al. · The Cancer Journal · 69
PAK Is Essential for RAS-Induced Upregulation of Cyclin D1 During the G1 to S Transition
2004 · Thao Nheu, Hong He, et al. · Cell Cycle · 67
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Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestine
2021 · Yumiko Hirokawa, Jordan Clarke, et al. · Communications Biology · 52
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Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.
2001 · H He, Y Hirokawa, et al. · PubMed · 49
Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
2023 · Tao Tan, Dmitri Mouradov, et al. · Cell Reports Medicine · 46
Colon Cryptogenesis: Asymmetric Budding
2013 · Chin Wee Tan, Yumiko Hirokawa, et al. · PLoS ONE · 42
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Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)
2006 · Yumiko Hirokawa, Alexander Levitzki, et al. · Cancer Letters · 39
Sichuan pepper extracts block the PAK1/Cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice
2006 · Yumiko Hirokawa, Thao Nheu, et al. · Cancer Biology & Therapy · 39
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Colonic myofibroblast cell line stimulates colonoid formation
2014 · Yumiko Hirokawa, Kelvin Hon Yan Yip, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 38
The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation
2004 · Hong He, Yumiko Hirokawa, et al. · Cancer Biology & Therapy · 38
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Signal therapy of NF1-deficient tumor xenograft in mice by the anti-PAK1 drug FK228
2005 · Yumiko Hirokawa, C. Oliver Hanemann, et al. · Cancer Biology & Therapy · 35
Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 34
Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts
2018 · Hon Yan Kelvin Yip, Chin Wee Tan, et al. · PLoS ONE · 29
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Analysis of Wnt signaling β-catenin spatial dynamics in HEK293T cells
2014 · Chin Tan, Bruce S Gardiner, et al. · BMC Systems Biology · 27
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Efficient Syntheses of Novel C2‘-Alkylated (±)-K252a Analogues
2001 · Kazuhiko Tamaki, J. Brad Shotwell, et al. · Organic Letters · 26
Antitumor activity of a new antibiotic, kazusamycin.
1985 · KANKI KOMIYAMA, KENJI OKADA, et al. · The Journal of Antibiotics · 26
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An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies.
2000 · H He, Y Hirokawa, et al. · PubMed · 22
Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Works count: 151
Citation count: 1,571
H-index: 23
I10-index: 31
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