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Kenji Sagawa

Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro
2004 · Kenji Maeda, Hirotomo Nakata, et al. · Journal of Virology · 221
Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5
2001 · Kenji Maeda, Kazuhisa Yoshimura, et al. · Journal of Biological Chemistry · 125
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The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31)
1997 · Kenji Sagawa, Teruaki Kimura, et al. · Journal of Biological Chemistry · 105
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Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists
2006 · Hiromu Habashita, Masaya Kokubo, et al. · Journal of Medicinal Chemistry · 82
Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31)
1997 · Kenji Sagawa, William Swaim, et al. · Journal of Biological Chemistry · 55
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Design and Synthesis of a Highly Selective EP2-Receptor Agonist
2001 · Kousuke Tani, Atsushi Naganawa, et al. · Bioorganic & Medicinal Chemistry Letters · 48
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite
2006 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry Letters · 47
Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives
2002 · Kousuke Tani, Atsushi Naganawa, et al. · Bioorganic & Medicinal Chemistry · 22
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists
2010 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry · 18
Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles
2009 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-Hydroxy-17,17-trimethylene 9β-chloro PGF derivatives
2002 · Kousuke Tani, Atsushi Naganawa, et al. · Bioorganic & Medicinal Chemistry · 16
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally available CCR5 selective antagonist
2011 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry · 11
Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate
2010 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry Letters · 9
Inhibitory effects of prostaglandin E1.ALPHA.-cyclodextrin (PGE1CD) on dimethylnitrosamine-induced acute liver damage in rats.
1995 · Akihiko SUZUKI, Masaichiro HAGINO, et al. · Folia Pharmacologica Japonica · 5
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Works count: 15
Citation count: 781
H-index: 11
I10-index: 12
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