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Robert Fledrich

Observed names: Fledrich, R, Fledrich, Robert, R Fledrich, R. Fledrich
Observed institutions: Max Planck Society, University of Münster, Universitätsmedizin Göttingen, University Hospital Leipzig, Max Planck Institute of Experimental Medicine, Max Planck Institute for Multidisciplinary Sciences, University of Göttingen, Leipzig University
ORCID: 0000-0001-5323-7958
Observed ORCID: 0000-0001-5323-7958
OpenAlex ID: A5036637334
A role for Schwann cell–derived neuregulin-1 in remyelination
2012 · Ruth M Stassart, Robert Fledrich, et al. · Nature Neuroscience · 302
Schwann cell functions in peripheral nerve development and repair
2022 · Mar Bosch-Queralt, Robert Fledrich, et al. · Neurobiology of Disease · 262
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Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A
2014 · Robert Fledrich, Ruth M Stassart, et al. · Nature Medicine · 196
Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity
2020 · Jolien Wolbert, Xiaolin Li, et al. · Proceedings of the National Academy of Sciences · 140
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Lithium enhances remyelination of peripheral nerves
2012 · Joelle Makoukji, Martin Belle, et al. · Proceedings of the National Academy of Sciences · 135
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Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
2018 · R. Fledrich, T. Abdelaal, et al. · Nature Communications · 119
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Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
2023 · Erik Schäffner, Mar Bosch-Queralt, et al. · Nature Neuroscience · 106
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Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
2023 · Venkat Krishnan Sundaram, Vlad Schütza, et al. · Cell Metabolism · 93
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Proteome profile of peripheral myelin in healthy mice and in a neuropathy model
2020 · Sophie B Siems, Olaf Jahn, et al. · eLife · 85
AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A
2021 · Benoit Gautier, Helene Hajjar, et al. · Nature Communications · 75
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A rat model of Charcot–Marie–Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients
2011 · Robert Fledrich, Beate Schlotter-Weigel, et al. · Brain · 71
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Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease
2012 · R. Fledrich, R. M. Stassart, et al. · British Medical Bulletin · 67
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
2019 · Robert Fledrich, Dagmar Akkermann, et al. · Nature Communications · 65
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The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration
2010 · Gerd Meyer zu Horste, Timo A. Miesbach, et al. · Neurobiology of Disease · 63
Axo-glial interdependence in peripheral nerve development
2019 · Robert Fledrich, Theresa Kungl, et al. · Development · 51
Sodium-Dependent Vitamin C Transporter 2 Deficiency Causes Hypomyelination and Extracellular Matrix Defects in the Peripheral Nervous System
2011 · Burkhard Gess, Dominik Röhr, et al. · Journal of Neuroscience · 50
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CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves
2020 · Maria A. Eichel, Vasiliki-Ilya Gargareta, et al. · Nature Communications · 44
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Biomarkers predict outcome in Charcot-Marie-Tooth disease 1A
2017 · Robert Fledrich, Manoj Mannil, et al. · Journal of Neurology Neurosurgery & Psychiatry · 31
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Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking
2015 · Julia Patzig, Kathrin Kusch, et al. · Glia · 30
Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model
2014 · Thomas Prukop, Dirk B. Epplen, et al. · The American Journal of Human Genetics · 27
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Early targeting of endoneurial macrophages alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot‐Marie‐Tooth 1A
2022 · Dennis Klein, Janos Groh, et al. · Glia · 24
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Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies
2025 · Michael Heming, Anna-Lena Börsch, et al. · Nature Communications · 19
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Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8
2025 · Nadège Hertzog, Mert Duman, et al. · Nature Communications · 16
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Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy
2019 · Sabitha Joseph, Siv Vingill, et al. · Journal of Neuroscience · 15
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases
2024 · Doris Krauter, Daniela Stausberg, et al. · EMBO Molecular Medicine · 11
Works count: 58
Citation count: 2,126
H-index: 21
I10-index: 25
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