Author

Thomas Kronbach

Observed names: Kronbach, T., T Kronbach, T. KRONBACH, T. Kronbach

Observed institutions: Goethe University Frankfurt, University of Geneva, Scripps Research Institute, United States Food and Drug Administration, Center for Drug Evaluation and Research, University of Illinois Urbana-Champaign, University of Basel, University Hospital of Geneva, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stanford Medicine, Scripps Clinic, BioCrea (Germany), Sandoz (Japan), University of Tübingen, Stanford University

OpenAlex ID: A5036729172

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1989 · T Kronbach, D Mathys, et al. · Molecular Pharmacology · 531

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 · Thomas Kronbach, Volker Fischer, et al. · Clinical Pharmacology & Therapeutics · 531

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1987 · Thomas Kronbach, Daniel Mathys, et al. · Analytical Biochemistry · 261

The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

1986 · U. A. Meyer, J. Gut, et al. · Xenobiotica · 130

Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.

1986 · J Gut, T Catin, et al. · Journal of Biological Chemistry · 111

Metabolism of Retigabine (D-23129), a Novel Anticonvulsant

1999 · Roland Hempel, Hubert Schupke, et al. · Drug Metabolism and Disposition · 90

In Vivo Efficacy in Airway Disease Models of N-(3,5-Dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), a Selective Phosphodiesterase 4 Inhibitor for Inhaled Administration

2003 · H. Kuss, N. Hoefgen, et al. · Journal of Pharmacology and Experimental Therapeutics · 87

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

1989 · Heyo K Kroemer, Gerd Mikus, et al. · Clinical Pharmacology & Therapeutics · 86

Retigabine N-Glucuronidation and Its Potential Role in Enterohepatic Circulation

1999 · Anita Hiller, Nghia Nguyen, et al. · Drug Metabolism and Disposition · 79

New metabolic pathways of alpha-lipoic acid.

2001 · H Schupke, R Hempel, et al. · PubMed · 78

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

2011 · Michael S. Malamas, Yike Ni, et al. · Journal of Medicinal Chemistry · 71

Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography

1985 · U.Thomas Meier, Thomas Kronbach, et al. · Analytical Biochemistry · 70

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism) — Increased michaelis constant (km) and loss of stereoselectivity of bufuralol 1′-hydroxylation in poor metabolizers

1984 · Pierre Dayer, Rodolfo Gasser, et al. · Biochemical and Biophysical Research Communications · 66

Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

2010 · Norbert Höfgen, Hans Stange, et al. · Journal of Medicinal Chemistry · 63

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation

1987 · Pierre Dayer, Thomas Kronbach, et al. · Biochemical Pharmacology · 61

Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4.

1989 · T Kronbach, T M Larabee, et al. · Proceedings of the National Academy of Sciences · 56

A simple high-performance liquid chromatographic pre-column technique for investigation of drug metabolism in biological fluids

1982 · Wolfgang Voelter, Thomas Kronbach, et al. · Journal of Chromatography A · 56

Debrisoquine‐type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

1984 · J. Gut, R. Gasser, et al. · FEBS Letters · 55

PDF

[49] Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6

1991 · Thomas Kronbach · Methods in enzymology on CD-ROM/Methods in enzymology · 54

Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

1985 · U Thomas Meier, Pierre Dayer, et al. · Clinical Pharmacology & Therapeutics · 53

A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1

1991 · Thomas Kronbach, Byron Kemper, et al. · Biochemistry · 51

Stereo- and regioselectivity of hepatic oxidation in man ? Effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation

1986 · P. Dayer, T. Leemann, et al. · European Journal of Clinical Pharmacology · 48

Purification and Characterization of Recombinant-Expressed Cytochrome P450 2C3 from Escherichia coli: 2C3 Encodes the 6β-Hydroxylase Deficient Form of P450-3b

1993 · T.H. Richardson, M.H. Hsu, et al. · Archives of Biochemistry and Biophysics · 46

An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5.

1991 · T Kronbach, E F Johnson · Journal of Biological Chemistry · 43

Properties of Expressed and Native Flavin-Containing Monooxygenases: Evidence of Multiple Forms in Rabbit Liver and Lung

1991 · Michael P. Lawton, Thomas Kronbach, et al. · Molecular Pharmacology · 32

Works count: 47

Citation count: 3,039

H-index: 26

I10-index: 35