Author

Christina J. Allain

Observed names: Christina Allain, Christina J Allain

Observed institutions: Boston College, Epizyme (United States), Eisai (Japan)

OpenAlex ID: A5041663671

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

2013 · Sarah K. Knutson, Natalie M. Warholic, et al. · Proceedings of the National Academy of Sciences · 810

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

2012 · Sarah K Knutson, Tim J Wigle, et al. · Nature Chemical Biology · 791

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

2013 · Scott R. Daigle, Edward J. Olhava, et al. · Blood · 737

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2 -Mutant Non-Hodgkin Lymphoma

2014 · Sarah K. Knutson, Satoshi Kawano, et al. · Molecular Cancer Therapeutics · 547

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

2019 · Andrew Fedoriw, Satyajit R. Rajapurkar, et al. · Cancer Cell · 357

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

2016 · Kevin W. Kuntz, John E. Campbell, et al. · Journal of Medicinal Chemistry · 186

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

2017 · Allison E. Drew, Oscar Moradei, et al. · Scientific Reports · 151

Nonclinical pharmacokinetics and metabolism of EPZ‐5676, a novel DOT1L histone methyltransferase inhibitor

2014 · Aravind Basavapathruni, Edward J. Olhava, et al. · Biopharmaceutics & Drug Disposition · 81

Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases

2008 · F. Douglas Ivey, Lili Wang, et al. · SLAS DISCOVERY · 38

New Classes of PDE7 Inhibitors Identified by a Fission Yeast-Based HTS

2010 · Manal A. Alaamery, Arlene R. Wyman, et al. · SLAS DISCOVERY · 35

Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

2017 · Ana Santos de Medeiros, Arlene R. Wyman, et al. · Cellular Signalling · 20

Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases

2010 · Didem Demirbas, Ozge Ceyhan, et al. · Cellular Signalling · 20

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

2010 · Roy M Pollock, Scott R Daigle, et al. · Blood · 10

Preclinical Characterization of a Potent, Selective Inhibitor of the Protein Methyltransferase DOT1L for Use in the Treatment of MLL-Rearranged Leukemia.

2012 · Roy M Pollock, Scott R Daigle, et al. · Blood · 5

Preclinical Characterization of E7438, a Potent, Selective Inhibitor of Protein Methyltransferase EZH2 with Robust Antitumor Activity Against EZH2 Mutated Non-Hodgkin Lymphoma Xenografts in Mice

2012 · Heike Keilhack, Akira Yokoi, et al. · Blood · 4

Data from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

2023 · Sarah K. Knutson, Satoshi Kawano, et al.

Supplementary Table 1 from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

2023 · Sarah K. Knutson, Satoshi Kawano, et al.

Supplementary Table 2 from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

2023 · Sarah K. Knutson, Satoshi Kawano, et al.

Supplementary Methods, Figure Legends from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

2023 · Sarah K. Knutson, Satoshi Kawano, et al.

Supplementary Figures 1 - 6 from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

2023 · Sarah K. Knutson, Satoshi Kawano, et al.

Data from Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

2023 · Sarah K. Knutson, Satoshi Kawano, et al.

Works count: 21

Citation count: 3,792

H-index: 12

I10-index: 13