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Federico Falchi

Observed names: F. Falchi, FALCHI FEDERICO, FALCHI Federico, FALCHI, FEDERICO, Falchi, Federico
Observed institutions: University of Siena, Italian Institute of Technology, Istituto di Genetica Molecolare, National Research Council, Dublin City University, Modélisation multi-échelle des systèmes urbains, University of Bologna, KU Leuven
ORCID: 0000-0001-7385-649X
Observed ORCID: 0000-0001-7385-649X
OpenAlex ID: A5042284243
Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation
2011 · Giovanni Maga, Federico Falchi, et al. · ChemMedChem · 109
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
2012 · Marco Radi, Federico Falchi, et al. · Bioorganic & Medicinal Chemistry Letters · 92
Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3
2008 · Giovanni Maga, Federico Falchi, et al. · Journal of Medicinal Chemistry · 87
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia
2018 · Elvira Sondo, Federico Falchi, et al. · Cell chemical biology · 72
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Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors
2011 · S. Schenone, C. Brullo, et al. · Current Medicinal Chemistry · 71
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
2020 · Greta Bagnolini, Domenico Milano, et al. · Journal of Medicinal Chemistry · 62
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Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells
2019 · Marinella Roberti, Fabrizio Schipani, et al. · European Journal of Medicinal Chemistry · 59
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Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication
2011 · A. Garbelli, M. Radi, et al. · Current Medicinal Chemistry · 59
Structure-Based Design of Small-Molecule Protein–Protein Interaction Modulators: The Story so Far
2014 · Federico Falchi, Fabiana Caporuscio, et al. · Future Medicinal Chemistry · 56
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents
2007 · Marco Radi, Emmanuele Crespan, et al. · Bioorganic & Medicinal Chemistry Letters · 56
Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification
2016 · Federico Falchi, Sine Mandrup Bertozzi, et al. · Analytical Chemistry · 52
2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile
2015 · Federica Prati, Christian Bergamini, et al. · Journal of Medicinal Chemistry · 51
N‐[2‐Methyl‐5‐(triazol‐1‐yl)phenyl]pyrimidin‐2‐amine as a Scaffold for the Synthesis of Inhibitors of Bcr‐Abl
2011 · Federica Arioli, Stella Borrelli, et al. · ChemMedChem · 50
Synthetic Lethality Triggered by Combining Olaparib with BRCA2–Rad51 Disruptors
2017 · Federico Falchi, Elisa Giacomini, et al. · ACS Chemical Biology · 47
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Computational techniques are valuable tools for the discovery of protein–protein interaction inhibitors: The 14-3-3σ case
2011 · Valentina Corradi, Manuela Mancini, et al. · Bioorganic & Medicinal Chemistry Letters · 42
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors
2015 · Cristina Tintori, Giuseppina La Sala, et al. · Journal of Medicinal Chemistry · 38
Probing allosteric communication with combined molecular dynamics simulations and network analysis
2024 · Mattia Bernetti, Stefano Bosio, et al. · Current Opinion in Structural Biology · 37
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase ( Tb GAPDH) and Trypanosoma cruzi trypanothione reductase ( Tc TR) and display trypanocidal activity
2017 · Elisa Uliassi, Giulia Fiorani, et al. · European Journal of Medicinal Chemistry · 35
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From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold
2015 · Angela Rampa, Francesca Mancini, et al. · Bioorganic & Medicinal Chemistry Letters · 35
Protein Tunnels: The Case of Urease Accessory Proteins
2017 · Francesco Musiani, Dario Gioia, et al. · Journal of Chemical Theory and Computation · 34
Chalcone-Based Carbamates for Alzheimer’S Disease Treatment
2017 · Angela Rampa, Serena Montanari, et al. · Future Medicinal Chemistry · 32
Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors
2015 · Sebastiano Rupiani, Rosa Buonfiglio, et al. · European Journal of Medicinal Chemistry · 31
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases
2017 · Sabrina Tassini, Liang Sun, et al. · Journal of Medicinal Chemistry · 30
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin‐Based Derivatives
2015 · Serena Montanari, Manuela Bartolini, et al. · ChemMedChem · 28
Targeting the Protein Tunnels of the Urease Accessory Complex: A Theoretical Investigation
2020 · Matteo Masetti, Federico Falchi, et al. · Molecules · 26
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Works count: 64
Citation count: 1,621
H-index: 25
I10-index: 41
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