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George A. Moniz
Observed names:
G. A. MONIZ,
G. A. Moniz,
G. Moniz,
George A Moniz,
George Moniz
Institution:
Biogen (United States)
Observed institutions:
University of Massachusetts Dartmouth,
Biogen (United States),
Amgen (United States),
Harvard University,
Yale University,
Eisai (United States),
Daicel Chiral Technologies (United States)
show all 7
OpenAlex ID:
A5043461259
E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling
2015
·
Sharon McGonigle
, Zhihong Chen
, et al.
·
Oncotarget
·
87
Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
2010
·
Murielle M. Véniant
, Clarence Hale
, et al.
·
Journal of Medicinal Chemistry
·
82
Development of a Rhodium Carbenoid-Initiated Claisen Rearrangement for the Enantioselective Synthesis of α-Hydroxy Carbonyl Compounds
1999
·
John L. Wood
, George A. Moniz
, et al.
·
Journal of the American Chemical Society
·
74
An Aldol-Based Synthesis of (+)-Peloruside A, A Potent Microtubule Stabilizing Agent
2009
·
David A. Evans
, Dennie S. Welch
, et al.
·
Journal of the American Chemical Society
·
67
Catalyst-Based Control of [2,3]- and [3,3]-Rearrangement in α-Diazoketone-Derived Propargyloxy Enols
2001
·
George A. Moniz
, John L. Wood
·
Journal of the American Chemical Society
·
62
A highly enantioselective catalyst for asymmetric hydroformylation of [2.2.1]-bicyclic olefins
2005
·
Jinkun Huang
, Emilio Bunel
, et al.
·
Tetrahedron Letters
·
56
A Baeyer-Villiger Oxidation Specifically Catalyzed by Human Flavin-Containing Monooxygenase 5
2010
·
W. George Lai
, Nadia Farah
, et al.
·
Drug Metabolism and Disposition
·
53
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice
2008
·
Lars Johansson
, Christopher Fotsch
, et al.
·
Journal of Medicinal Chemistry
·
49
Rhodium Carbenoid-Initiated Claisen Rearrangement: Scope and Mechanistic Observations
1999
·
John L. Wood
, George A. Moniz
·
Organic Letters
·
48
Efficient Syntheses of (α-Fluoropropargyl)phosphonate Esters
1996
·
Farid Benayoud
, Daniel J. deMendonca
, et al.
·
The Journal of Organic Chemistry
·
46
The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors
2007
·
Chester Yuan
, David J. St. Jean
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
41
Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases
2020
·
Bin Ma
, Tonika Bohnert
, et al.
·
Journal of Medicinal Chemistry
·
40
Dynamic Biphasic Counterion Exchange in a Configurationally Stable Aziridinium Ion: Efficient Synthesis and Isolation of a Koga C2-Symmetric Tetraamine Base
2007
·
Matthew J. Frizzle
, Sebastien Caille
, et al.
·
Organic Process Research & Development
·
32
Selective protodeboronation: synthesis of 4-methyl-2-thiopheneboronic anhydride and demonstration of its utility in Suzuki–Miyaura reactions
2007
·
Liane M. Klingensmith
, Matthew M. Bio
, et al.
·
Tetrahedron Letters
·
29
Synthesis of α-fluoro-β, γ-alkenylphosphonates and conjugated fluoroenynes from a common intermediate (α-fluoropropargyl) phosphonate
1998
·
Farid Benayoud
, Ling Chen
, et al.
·
Tetrahedron
·
21
Comparison of Large-Scale Routes to Manufacture Chiral exo-2-Norbornyl Thiourea
2009
·
Seb Caille
, Jerome Boni
, et al.
·
Organic Process Research & Development
·
16
Asymmetric alkylation of 5-alkyl-2-aminothiazolones using a C2-symmetric chiral tetraamine base
2011
·
Matthew J. Frizzle
, Roger R. Nani
, et al.
·
Tetrahedron Letters
·
11
A highly efficient resolution protocol for 2′-halo-α-methylbenzylamines
2007
·
Liane M. Klingensmith
, Kelly A. Nadeau
, et al.
·
Tetrahedron Letters
·
11
Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068
2020
·
Chaomin Li
, Lloyd Franklin
, et al.
·
Organic Process Research & Development
·
8
Identification of Ambergris from the New Bedford Whaling Museum by Nuclear Magnetic Resonance Spectroscopy
1996
·
George A Moniz
, Gerald B Hammond
·
Journal of AOAC International
·
8
Abstract 4688: E7449: A novel PARP inhibitor enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors
2012
·
Sharon McGonigle
, Zhihong Chen
, et al.
·
Cancer Research
·
5
Development of an Efficient Manufacturing Process for E2212 toward Rapid Clinical Introduction
2019
·
Minetaka Isomura
, Taiju Nakamura
, et al.
·
Organic Process Research & Development
·
3
Effects of solvent on chiral and enantiomeric separation of Koga bases using derivatized amylose chiral stationary phase
2009
·
Hong‐Xun Guo
, Steven Wu
, et al.
·
Chirality
·
2
On the relocation of the amino functionality to the ethyl side chain in aminoglutethimide: Synthesis and aromatase‐inhibitory activity of 3‐(2′‐N,N‐diethyl‐amino)ethyl‐3‐phenylpiperidine‐2,6‐dione
1997
·
George A. Moniz
, Gerald B. Hammond
·
Journal of Heterocyclic Chemistry
·
2
A green bromination process for synthesis of a novel drug candidate
2014
·
Steven R. Mathieu
, George A. Moniz
·
Tetrahedron Letters
·
1
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Works count:
41
Citation count:
857
H-index:
16
I10-index:
18
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