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Noriyasu Haginoya

Observed names: Haginoya, Noriyasu, N. HAGINOYA, N. Haginoya
OpenAlex ID: A5043627463
Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Journal of Medicinal Chemistry · 74
Nucleosides and Nucleotides. 160. Synthesis of Oligodeoxyribonucleotides Containing 5-(N-Aminoalkyl)carbamoyl-2‘-deoxyuridines by a New Postsynthetic Modification Method and Their Thermal Stability and Nuclease-Resistance Properties
1997 · Noriyasu Haginoya, Akira Ono, et al. · Bioconjugate Chemistry · 51
DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model
2019 · Takeshi Jimbo, Mana Hatanaka, et al. · Oncotarget · 49
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Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties
2009 · Kenji Yoshikawa, Shozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 45
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa
2008 · Tsutomu Nagata, Toshiharu Yoshino, et al. · Bioorganic & Medicinal Chemistry · 43
Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification
2005 · Satoshi Komoriya, Shozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 42
Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationships
2011 · Takao Horiuchi, Yasuyuki Takeda, et al. · Chemical and Pharmaceutical Bulletin · 40
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A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1
2023 · Masashi Numata, Noriyasu Haginoya, et al. · Cancer Cell International · 35
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Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 34
Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors
2007 · Tsutomu Nagata, Toshiharu Yoshino, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Nucleosides and nucleotides. 127. A novel and convenient post-synthetic modification method for the synthesis of oligodeoxyribonucleotides carrying amino linkers at the 5-position of 2′-deoxyuridine
1994 · Akira Ono, Noriyasu Haginoya, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties
2009 · Kenji Yoshikawa, Aki Yokomizo, et al. · Bioorganic & Medicinal Chemistry · 31
Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
2005 · Satoshi Komoriya, Noriyasu Haginoya, et al. · Bioorganic & Medicinal Chemistry · 29
Discovery of DF-461, a Potent Squalene Synthase Inhibitor
2013 · Masanori Ichikawa, Masami Ohtsuka, et al. · ACS Medicinal Chemistry Letters · 27
Effects of 5-(N-Aminohexyl)Carbamoyl-2'-Deoxyuridine on Endonuclease Stability and the Ability of Oligodeoxynucleotide to Activate RNase H
1997 · Y. Ueno, I. Kumagai, et al. · Nucleic Acids Research · 24
Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors
2011 · Masanori Ichikawa, Aki Yokomizo, et al. · Bioorganic & Medicinal Chemistry · 23
Facile Methods for Preparation of Thiazolopyridine and Tetrahydro-thiazolopyridine Derivatives
2004 · Noriyasu Haginoya, Satoshi Komoriya, et al. · Heterocycles · 22
Discovery of novel tricyclic compounds as squalene synthase inhibitors
2012 · Masanori Ichikawa, Masami Ohtsuka, et al. · Bioorganic & Medicinal Chemistry · 21
Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Nucleosides and nucleotides. 161. Incorporation of 5-(N-aminoalkyl)carbamoyl-2′-deoxycytidines into oligodeoxyribonucleotides by a convenient post-synthetic modification method
1996 · Yukari Nomura, Noriyasu Haginoya, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors
2024 · Noriyasu Haginoya, Masanori Suzuki, et al. · Journal of Medicinal Chemistry · 5
A Facile Synthesis of 5,6-Dihydro-4H-pyrrolo[3,4-d]thiazole and Other Pyrrolidine-Fused Aromatic Ring Systems via One-Step Cyclization from Diols
2012 · Kenji Yoshikawa, Tsutomu Nagata, et al. · Heterocycles · 4
P3.02-042 DS-1205b, a Novel, Selective, Inhibitor of AXL, Delays the Onset of Resistance and Overcomes Acquired Resistance to EGFR-TKIs
2017 · T. Jimbo, T. Taira, et al. · Journal of Thoracic Oncology · 1
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DS-1205b, a novel, selective, small-molecule inhibitor of AXL, delays the onset of resistance and overcomes acquired resistance to EGFR-TKIs in a human EGFR-mutant NSCLC (T790M-negative) xenograft model
2017 · T. Jimbo, T. Taira, et al. · Annals of Oncology · 1
Abstract 1132: Development and characterization of a novel orally bioavailable menin-MLL inhibitor for treatment of acute leukemia patients with MLL-rearrangement or NPM1 mutation
2021 · Masashi Numata, Machiko Shiroishi, et al. · Cancer Research
Works count: 36
Citation count: 701
H-index: 19
I10-index: 20
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