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Joel A. Cassel
Observed names:
J Cassel,
J.A. Cassel,
Joel A Cassel,
Joel Cassel
Institution:
The Wistar Institute
Observed institutions:
The Wistar Institute,
University of California San Diego,
Vironika (United States),
ALS Biopharma (United States),
AstraZeneca (United States),
Montreal Clinical Research Institute
show all 6
ORCID:
0000-0001-8465-8739
Observed ORCID:
0000-0001-8465-8739
OpenAlex ID:
A5044366210
Loperamide (ADL 2-1294), an Opioid Antihyperalgesic Agent with Peripheral Selectivity
1999
·
D.L. DeHaven-Hudkins
, L. Cortes Burgos
, et al.
·
Journal of Pharmacology and Experimental Therapeutics
·
145
Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth
2019
·
Troy E. Messick
, Garry R. Smith
, et al.
·
Science Translational Medicine
·
128
Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer
2023
·
Clare M. Adams
, Ramkrishna Mitra
, et al.
·
Cancer Discovery
·
117
PDF
Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth
2021
·
Katelyn D. Miller
, Katherine Pniewski
, et al.
·
Cancer Research
·
98
SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1
2021
·
Ariel Shepley-McTaggart
, Cari A. Sagum
, et al.
·
PLoS ONE
·
94
PDF
Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)
2008
·
Bertrand Le Bourdonnec
, Rolf T. Windh
, et al.
·
Journal of Medicinal Chemistry
·
92
Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation
2015
·
Alyssa N. Coyne
, Shizuka B. Yamada
, et al.
·
Human Molecular Genetics
·
90
Synthesis and Biological Activities of Cyclic Lanthionine Enkephalin Analogues: δ-Opioid Receptor Selective Ligands
2002
·
Yosup Rew
, Shelle Malkmus
, et al.
·
Journal of Medicinal Chemistry
·
90
Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery ofN,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)
2009
·
Bertrand Le Bourdonnec
, Rolf T. Windh
, et al.
·
Journal of Medicinal Chemistry
·
87
Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors
2022
·
Ali Vaziri-Gohar
, Joel Cassel
, et al.
·
Nature Cancer
·
86
PDF
Metabolic control of BRISC–SHMT2 assembly regulates immune signalling
2019
·
Miriam Walden
, Lei Tian
, et al.
·
Nature
·
85
[3H]Alvimopan binding to the μ opioid receptor: Comparative binding kinetics of opioid antagonists
2005
·
Joel A. Cassel
, Jeffrey D. Daubert
, et al.
·
European Journal of Pharmacology
·
74
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: Characterization of inhibition by nucleic acids and 4-aminoquinolines
2013
·
Joel A. Cassel
, Allen B. Reitz
·
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
·
65
RETRACTED ARTICLE: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
2020
·
Kumar Sachin Singh
, Rishabh Sharma
, et al.
·
Nature
·
56
Endomorphins fully activate a cloned human mu opioid receptor
1998
·
Jianhua Gong
, Judith A Strong
, et al.
·
FEBS Letters
·
52
Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers
2023
·
Devivasha Bordoloi
, Abhijeet J. Kulkarni
, et al.
·
Science Advances
·
47
PDF
Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A -Mutant Ovarian Cancers
2021
·
Joseph A. Zundell
, Takeshi Fukumoto
, et al.
·
Cancer Research
·
36
PDF
The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria
2021
·
Christopher W. Schultz
, Grace A. McCarthy
, et al.
·
Molecular Cancer Therapeutics
·
34
Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ
2012
·
Joel A. Cassel
, Sergey Ilyin
, et al.
·
Bioorganic & Medicinal Chemistry
·
34
[Pro3]Dyn A(1−11)-NH2: A Dynorphin Analogue with High Selectivity for the κ Opioid Receptor
2000
·
Georg Schlechtingen
, Li Zhang
, et al.
·
Journal of Medicinal Chemistry
·
33
ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
2024
·
Sabina I. Hlavaty
, Kelsey N. Salcido
, et al.
·
Cell Reports
·
31
Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function
2012
·
Joel A. Cassel
, Mark E. McDonnell
, et al.
·
Biochimie
·
31
A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors
2020
·
Thibaut Barnoud
, Jessica C. Leung
, et al.
·
Cancer Research
·
30
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
2023
·
Yange Cui
, Luyang Wang
, et al.
·
Nature Communications
·
29
PDF
Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
2022
·
Jagadish C. Ghosh
, Michela Perego
, et al.
·
Proceedings of the National Academy of Sciences
·
29
PDF
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Works count:
256
Citation count:
2,381
H-index:
27
I10-index:
51
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