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Bryan A. Laffitte

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis
2001 · Ajay Chawla, William A. Boisvert, et al. · Molecular Cell · 1,345
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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
2003 · Sean B. Joseph, Antonio Castrillo, et al. · Nature Medicine · 1,156
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα
2000 · Asha Venkateswaran, Bryan A. Laffitte, et al. · Proceedings of the National Academy of Sciences · 1,004
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
2002 · Sean B. Joseph, Elaine McKilligin, et al. · Proceedings of the National Academy of Sciences · 947
Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors
2002 · Sean B. Joseph, Bryan A. Laffitte, et al. · Journal of Biological Chemistry · 780
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
2001 · Bryan A. Laffitte, Joyce J. Repa, et al. · Proceedings of the National Academy of Sciences · 683
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
2003 · Bryan A. Laffitte, Lily C. Chao, et al. · Proceedings of the National Academy of Sciences · 502
Identification of macrophage liver X receptors as inhibitors of atherosclerosis
2002 · Rajendra K. Tangirala, Eric D. Bischoff, et al. · Proceedings of the National Academy of Sciences · 438
Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids
2001 · Heidi Rachelle Kast, Catherine M. Nguyen, et al. · Molecular Endocrinology · 336
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Autoregulation of the Human Liver X Receptor α Promoter
2001 · Bryan A. Laffitte, Sean B. Joseph, et al. · Molecular and Cellular Biology · 315
GPR68 Senses Flow and Is Essential for Vascular Physiology
2018 · Jie Xu, Jayanti Mathur, et al. · Cell · 312
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Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor
2000 · Bryan A. Laffitte, Heidi Rachelle Kast, et al. · Journal of Biological Chemistry · 275
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Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages
2002 · Puiying A. Mak, Bryan A. Laffitte, et al. · Journal of Biological Chemistry · 244
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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
2017 · David C. Tully, Paul V. Rucker, et al. · Journal of Medicinal Chemistry · 237
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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
2015 · Weijun Shen, Brandon Taylor, et al. · Nature Communications · 203
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The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions
2003 · Bryan A. Laffitte, Sean B. Joseph, et al. · Molecular and Cellular Biology · 163
Liver X receptors are regulators of adipocyte gene expression but not differentiation
2004 · Sarah Hummasti, Bryan A. Laffitte, et al. · Journal of Lipid Research · 120
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency
2010 · Rodolfo Gonzalez, Lori L. Jennings, et al. · Proceedings of the National Academy of Sciences · 104
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis
2020 · Donatella Chianelli, Paul V. Rucker, et al. · Journal of Medicinal Chemistry · 103
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Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening
2013 · Weijun Shen, Matthew S. Tremblay, et al. · Journal of the American Chemical Society · 97
Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
2019 · Eloy D. Hernandez, Lianxing Zheng, et al. · Hepatology Communications · 95
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Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth
2013 · Jinyun Chen, Franklin Chung, et al. · Oncotarget · 82
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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133
2020 · Yahu A. Liu, Qihui Jin, et al. · Journal of Medicinal Chemistry · 77
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers
2019 · Michael K. Badman, Jin Chen, et al. · Clinical Pharmacology in Drug Development · 75
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Transcription of the Vascular Endothelial Growth Factor Gene in Macrophages Is Regulated by Liver X Receptors
2004 · Robert Walczak, Sean B. Joseph, et al. · Journal of Biological Chemistry · 71
Works count: 52
Citation count: 10,120
H-index: 30
I10-index: 34
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