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Brian A. Johns

In VitroAntiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor
2010 · Masanori Kobayashi, Tomokazu Yoshinaga, et al. · Antimicrobial Agents and Chemotherapy · 383
Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes
2011 · Kendra E. Hightower, Ruolan Wang, et al. · Antimicrobial Agents and Chemotherapy · 226
Total Synthesis of (+)-Discodermolide
1998 · James A. Marshall, Brian A. Johns · The Journal of Organic Chemistry · 196
Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)
2013 · Brian A. Johns, Takashi Kawasuji, et al. · Journal of Medicinal Chemistry · 190
Synthesis and Biological Evaluation of Aza-C-disaccharides: (1→6), (1→4), and (1→1) Linked Sugar Mimics
1997 · Brian A. Johns, Y. T. Pan, et al. · Journal of the American Chemical Society · 128
Imidazo[1,2-a]pyridines with potent activity against herpesviruses
2007 · Kristjan S. Gudmundsson, Brian A. Johns · Bioorganic & Medicinal Chemistry Letters · 122
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore
2009 · Brian A. Johns, Jason G. Weatherhead, et al. · Bioorganic & Medicinal Chemistry Letters · 114
CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption
2020 · Justin Harper, Shari Gordon, et al. · Nature Medicine · 106
Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles
2013 · Takashi Kawasuji, Brian A. Johns, et al. · Journal of Medicinal Chemistry · 97
Antiviral Characteristics of GSK1265744, an HIV Integrase Inhibitor Dosed Orally or by Long-Acting Injection
2014 · Tomokazu Yoshinaga, Masanori Kobayashi, et al. · Antimicrobial Agents and Chemotherapy · 96
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The Activity of the Integrase Inhibitor Dolutegravir Against HIV-1 Variants Isolated From Raltegravir-Treated Adults
2012 · Mark R. Underwood, Brian A. Johns, et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 93
1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position
2009 · Brian A. Johns, Jason G. Weatherhead, et al. · Bioorganic & Medicinal Chemistry Letters · 93
Synthesis of Novel Imidazo[1,2-a]pyridines with Potent Activity against Herpesviruses
2003 · Kristjan S. Gudmundsson, Brian A. Johns · Organic Letters · 91
Synthesis of Discodermolide Subunits by SE2‘ Addition of Nonracemic Allenylstannanes to Aldehydes
1998 · James A. Marshall, Zhi-Hui Lu, et al. · The Journal of Organic Chemistry · 85
The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral
2007 · Edward P. Garvey, Brian A. Johns, et al. · Antimicrobial Agents and Chemotherapy · 74
Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses
2009 · Kristjan S. Gudmundsson, Brian A. Johns, et al. · Bioorganic & Medicinal Chemistry Letters · 66
Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity
2007 · Kristjan S. Gudmundsson, Brian A. Johns, et al. · Bioorganic & Medicinal Chemistry Letters · 62
Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore
2012 · Takashi Kawasuji, Brian A. Johns, et al. · Journal of Medicinal Chemistry · 61
Conformational Behavior of Aza-C-Glycosides: Experimental Demonstration of the Relative Role of the exo-anomeric Effect and 1,3-Type Interactions in Controlling the Conformation of Regular Glycosides
1999 · Juan Luis Asensio, F. Javier Cañada, et al. · Journal of the American Chemical Society · 60
Pyrazolo[1,5-a]pyridines: synthetic approaches to a novel class of antiherpetics
2003 · Brian A Johns, Kristjan S Gudmundsson, et al. · Tetrahedron · 59
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses
2005 · Kristjan S. Gudmundsson, Brian A. Johns, et al. · Bioorganic & Medicinal Chemistry · 58
Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents
2005 · Brian A. Johns, Kristjan S. Gudmundsson, et al. · Bioorganic & Medicinal Chemistry · 58
Scaffolded bis-azasugars: A dual warhead approach to glycosidase inhibition
1998 · Brian A. Johns, Carl R. Johnson · Tetrahedron Letters · 55
Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase
2013 · Andrew Maynard, Renae M. Crosby, et al. · Journal of Medicinal Chemistry · 54
Advances in two-metal chelation inhibitors of HIV integrase
2008 · Brian A Johns, Angilique C Svolto · Expert Opinion on Therapeutic Patents · 54
Works count: 77
Citation count: 3,350
H-index: 31
I10-index: 50
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