Author

Elwood E. Largis

Observed names: E E Largis, E. E. LARGIS, E. E. Largis, E. Largis, E.E. Largis, Elwood E Largis, Elwood F. Largis, Elwood Largis, Largis, Elwood Eugene

Institution: Wyeth

Observed institutions: Cleveland Clinic, University of North Dakota, Armed Forces Institute of Pathology, Indiana University Indianapolis, Indiana University School of Medicine, Wyeth, The Ohio State University

OpenAlex ID: A5049529862

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent

1992 · Jonathan D. Bloom, Minu D. Dutia, et al. · Journal of Medicinal Chemistry · 295

Hypercholesterolemia in the Rabbit Induced by Feeding Graded Amounts of Low-Level Cholesterol

1996 · Frank D. Kolodgie, Andrew S. Katocs, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 146

CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.

1989 · E E Largis, C H Wang, et al. · Journal of Lipid Research · 125

Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines.

1994 · J A Dolan, H A Muenkel, et al. · Journal of Pharmacology and Experimental Therapeutics · 78

Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human β3 Agonists

2001 · Baihua Hu, John Ellingboe, et al. · Bioorganic & Medicinal Chemistry · 44

2,4-thiazolidinediones as potent and selective human β3 agonists

2001 · Baihua Hu, John Ellingboe, et al. · Bioorganic & Medicinal Chemistry Letters · 44

Antidiabetic and antiobesity effects of a highly selective β3‐adrenoceptor agonist (CL 316,243)

1994 · Elwood E. Largis, Michael G. Burns, et al. · Drug Development Research · 43

Potential antiatherosclerotic agents. 5. An acyl-coenzyme A:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity

1986 · Vern G. DeVries, Sheldon A. Schaffer, et al. · Journal of Medicinal Chemistry · 36

Continuous monitoring of lipolytic rates in perifused isolated fat cells.

1973 · D O Allen, E E Largis, et al. · Journal of Applied Physiology · 33

Perifused Fat Cells

1973 · Andrew S. Katocs, Elwood E. Largis, et al. · Journal of Biological Chemistry · 29

Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogs

1989 · Vern G. DeVries, Jonathan D. Bloom, et al. · Journal of Medicinal Chemistry · 28

Prodrugs of CL316243: a selective β3-adrenergic receptor agonist for treating obesity and diabetes

1999 · F.W. Sum, A. Gilbert, et al. · Bioorganic & Medicinal Chemistry Letters · 25

(4-Piperidin-1-yl)phenyl Amides: Potent and Selective Human β3 Agonists

2001 · Baihua Hu, John Ellingboe, et al. · Journal of Medicinal Chemistry · 23

Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogs of cetaben

1983 · J. Donald Albright, Vern G. DeVries, et al. · Journal of Medicinal Chemistry · 23

Potential antiatherosclerotic agents. 3. Substituted benzoic and nonbenzoic acid analogs of cetaben

1983 · J. Donald Albright, Vern G. DeVries, et al. · Journal of Medicinal Chemistry · 23

Role of Ca2+ in Adrenocorticotropic Hormone-stimulated Lipolysis in the Perifused Fat Cell System

1974 · Andrew S. Katocs, Elwood E. Largis, et al. · Journal of Biological Chemistry · 23

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

2003 · Fuk-Wah Sum, Victoria Wong, et al. · Bioorganic & Medicinal Chemistry Letters · 22

New oxadiazolidinedione derivatives as potent and selective human β3 agonists

2001 · Baihua Hu, Michael Malamas, et al. · Bioorganic & Medicinal Chemistry Letters · 22

The effects of endothelial cell-conditioned media on the proliferation of aortic smooth muscle cells and 3T3 cells in culture.

1981 · C H Wang, E E Largis, et al. · PubMed · 18

4-Aminopiperidine ureas as potent selective agonists of the human β3-Adrenergic receptor

2001 · Mark A Ashwell, William R Solvibile, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Potential antiatherosclerotic agents. 4. [(Functionalized-alkyl)amino]benzoic acid analogs of cetaben

1983 · Vern G. DeVries, Elwood E. Largis, et al. · Journal of Medicinal Chemistry · 16

Antilipolytic Action of Tolbutamide in Isolated Fat Cells of the Rat

1974 · Donald O Allen, Elwood E Largis, et al. · Diabetes · 13

Isoproterenol and glucagon effects in perfused hearts from spontaneously hypertensive and normotensive rats

1973 · Elwood E. Largis, Donald O. Allen, et al. · Biochemical Pharmacology · 13

Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 2: Arylethanolaminomethylpiperidines

2002 · Robert J. Steffan, Mark A. Ashwell, et al. · Bioorganic & Medicinal Chemistry Letters · 10

Effects of phlorizin on glucose transport into blood and lymph

1971 · Elwood E. Largis, Francis A. Jacobs · Biochimica et Biophysica Acta (BBA) - Biomembranes · 10

Works count: 43

Citation count: 1,197

H-index: 18

I10-index: 25