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Donna M. Carr

Observed names: Carr, Donna M, D. Carr, Donna Carr
OpenAlex ID: A5050801977
Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors
2013 · Erick J. Morris, Sharda Jha, et al. · Cancer Discovery · 664
Selective small-molecule inhibition of an RNA structural element
2015 · John A. Howe, Hao Wang, et al. · Nature · 403
Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules
2000 · Hena R. Ashar, Linda James, et al. · Journal of Biological Chemistry · 317
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Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I
1997 · Fang L. Zhang, Paul Kirschmeier, et al. · Journal of Biological Chemistry · 196
Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors
2009 · Thierry O. Fischmann, Catherine K. Smith, et al. · Biochemistry · 187
Novel Tricyclic Inhibitors of Farnesyl Protein Transferase
1995 · W. Robert Bishop, Richard Bond, et al. · Journal of Biological Chemistry · 152
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Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors
2018 · Stergios J. Moschos, Ryan J. Sullivan, et al. · JCI Insight · 151
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Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex
1997 · A.G. Taveras, S.W. Remiszewski, et al. · Bioorganic & Medicinal Chemistry · 122
The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines
2001 · Hena R. Ashar, Linda James, et al. · Experimental Cell Research · 109
Exploring the Pharmacokinetic/Pharmacodynamic Relationship of Relebactam (MK-7655) in Combination with Imipenem in a Hollow-Fiber Infection Model
2018 · Jin Wu, Fred Racine, et al. · Antimicrobial Agents and Chemotherapy · 60
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology
2018 · Sobhana Babu Boga, Yongqi Deng, et al. · ACS Medicinal Chemistry Letters · 53
Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms
2016 · Ling Tong, Wensheng Yu, et al. · Journal of Medicinal Chemistry · 51
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Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase
2014 · Yongqi Deng, Gerald W. Shipps, et al. · Journal of Medicinal Chemistry · 49
A translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam
2019 · Pratik Bhagunde, Zufei Zhang, et al. · International Journal of Infectious Diseases · 44
Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation
1997 · A.K. Mallams, F.G. Njoroge, et al. · Bioorganic & Medicinal Chemistry · 42
Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c.
1993 · Stuart W McCombie, Robert W Bishop, et al. · Bioorganic & Medicinal Chemistry Letters · 35
Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine
1998 · Alan K. Mallams, Randall R. Rossman, et al. · Journal of Medicinal Chemistry · 27
Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor
2017 · Scott S. Walker, David Degen, et al. · ACS Chemical Biology · 18
Structure–activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors
2016 · Ling Tong, Wensheng Yu, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742
2016 · Wensheng Yu, Craig A. Coburn, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities
1999 · Arthur G. Taveras, Jeff Deskus, et al. · Journal of Medicinal Chemistry · 17
Expression and purification of phosphorylated and non-phosphorylated human MEK1
2006 · Catherine K. Smith, Donna Carr, et al. · Protein Expression and Purification · 15
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology
2018 · Sobhana Babu Boga, Abdul-Basit Alhassan, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions
2018 · Wensheng Yu, Ling Tong, et al. · Journal of Medicinal Chemistry · 14
Discovery of potent macrocyclic HCV NS5A inhibitors
2016 · Wensheng Yu, Bancha Vibulbhan, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Works count: 39
Citation count: 2,834
H-index: 18
I10-index: 27
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