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Grace Wing-Yan Mak

Observed names: G W Y Mak, G. Mak, Grace Mak, Grace W Y Mak, Grace W. Mak, Grace W. Y. Mak, Grace W.Y. Mak
ORCID: 0000-0003-2861-6221
Observed ORCID: 0000-0003-2861-6221
OpenAlex ID: A5054009552
Overexpression of a Novel Activator of PAK4, the CDK5 Kinase–Associated Protein CDK5RAP3, Promotes Hepatocellular Carcinoma Metastasis
2011 · Grace Wing-Yan Mak, Mandy Man-Lok Chan, et al. · Cancer Research · 92
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Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
2013 · Sébastien Naud, Isaac M. Westwood, et al. · Journal of Medicinal Chemistry · 81
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2019 · Simon J. Anderhub, Grace Wing-Yan Mak, et al. · Molecular Cancer Therapeutics · 43
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d ]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N 2-(2-Ethoxy-4-(4-methyl-4 H -1,2,4-triazol-3-yl)phenyl)-6-methyl- N 8-neopentylpyrido[3,4- d ]pyrimidine-2,8-diamine (BOS172722)
2018 · Hannah L. Woodward, Paolo Innocenti, et al. · Journal of Medicinal Chemistry · 40
Rapid Discovery of Pyrido[3,4- d ]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach
2016 · Paolo Innocenti, Hannah L. Woodward, et al. · Journal of Medicinal Chemistry · 36
Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
2015 · Mark D. Gurden, Isaac M. Westwood, et al. · Cancer Research · 34
CDK5RAP3 Is a Novel Repressor of p14ARF in Hepatocellular Carcinoma Cells
2012 · Grace Wing-Yan Mak, Wai-Lung Lai, et al. · PLoS ONE · 34
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The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells
2012 · Chi-Hang Wong, Grace Wing-Yan Mak, et al. · Cytokine · 30
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy
2017 · Amir Faisal, Grace W Y Mak, et al. · British Journal of Cancer · 28
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Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736
2020 · Andrew S. Moore, Amir Faisal, et al. · Blood Advances · 27
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Green fluorescent protein induces the secretion of inflammatory cytokine interleukin-6 in muscle cells
2007 · Grace Wing-Yan Mak, Chi-Hang Wong, et al. · Analytical Biochemistry · 10
Impact of G2 checkpoint defect on centromeric instability
2010 · W Deng, S W Tsao, et al. · Oncogene · 6
Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes
2023 · François Saint-Dizier, Thomas P. Matthews, et al. · Journal of Medicinal Chemistry · 5
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Abstract 193: Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate
2017 · Hannah L. Woodward, Paolo Innocenti, et al. · Cancer Research · 2
T-cell receptors targeting distinct FLT3-D835Y neoantigens display differential reactivity toward acute myeloid leukemia
2026 · Nadine E. Struckman, M. Willy Honders, et al. · Blood Immunology & Cellular Therapy
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Data from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Table S3 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Figure S3 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Table S2 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Figure S1 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Figure S2 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Table S1 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Figure S4 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Table S2 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Supplementary Figure S2 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2023 · Simon J. Anderhub, Grace Wing-Yan Mak, et al.
Works count: 50
Citation count: 468
H-index: 10
I10-index: 11
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