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Michael Tarpley

Observed name: Michael T. Tarpley
Observed institution: North Carolina Central University
ORCID: 0009-0007-3712-7194
Observed ORCID: 0009-0007-3712-7194
OpenAlex ID: A5055106514
Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction
2019 · Eric W. Fish, Laura B. Murdaugh, et al. · Scientific Reports · 106
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Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells
2017 · Scott J. Sauer, Michael Tarpley, et al. · Carcinogenesis · 86
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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies
2021 · Michael Tarpley, Helen O. Oladapo, et al. · European Journal of Pharmaceutical Sciences · 46
Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies
2017 · Jay Arora, Scott J. Sauer, et al. · Oncotarget · 46
Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1
2017 · Ben K. Ehe, David R. Lamson, et al. · Biochemical and Biophysical Research Communications · 38
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells
2017 · Helen O. Oladapo, Michael Tarpley, et al. · Cancer Letters · 34
Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol‐induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder
2022 · Derek F. Burton, Oswald M. Boa‐Amponsem, et al. · Journal of Neuroscience Research · 16
Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form
2014 · Alan J. House, Laura R. Daye, et al. · Archives of Biochemistry and Biophysics · 7
Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids
2024 · Goran Poje, Davor Šakić, et al. · Acta Pharmaceutica · 5
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Identification of Novel GANT61 Analogs with Activity in Hedgehog Functional Assays and GLI1-Dependent Cancer Cells
2024 · Dina Abu Rabe, Lhoucine Chdid, et al. · Molecules · 5
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Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening
2021 · Michael Tarpley, Thomas B. Caligan, et al. · MethodsX · 5
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Data on peptides identified by mass spectrometry analysis of in vitro DYRK1A-mediated phosphorylation sites on GLI1
2017 · Ben K. Ehe, David R. Lamson, et al. · Data in Brief · 3
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Abstract A138: Profiling of harmine and select analogs as differential inhibitors of DYRK1A and monoamine oxidase A: Exploring the potential for anti-cancer efficacy and minimizing off-target activity
2019 · Hassan Shehata, Michael Tarpley, et al. · Molecular Cancer Therapeutics · 2
Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays
2024 · David R. Lamson, Michael Tarpley, et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 1
Data supporting a pilot high-throughput screen of a drug library for identification of DYRK1A inhibitors and high-content imaging analysis of identified harmine analogs
2021 · Michael Tarpley, Helen Oladapo, et al. · Data in Brief · 1
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From in silico prediction to experimental validation: Identification of drugs and novel synergistic combinations that inhibit growth of inflammatory breast cancer cells
2026 · Esraa A. Salim, Xiaojia Ji, et al. · PLoS ONE
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Abstract A086: AI-assisted identification and lab-based validation of novel hedgehog pathway inhibitors targeting the downstream GLI transcription effectors
2026 · Ahmed Elobeid, Xiaojia Ji, et al. · Clinical Cancer Research
The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects
2026 · Xiaojia Ji, Esraa Salim, et al. · Advances in experimental medicine and biology
Abstract A018: Accelerating drug discovery at an HBCU with AI/ML: Text mining, computational modeling, and drug repurposing approaches
2025 · Kevin P. Williams, Xiaojia Ji, et al. · Clinical Cancer Research
Abstract C100: Identification and functional characterization of a novel GLI1 splice variant in breast cancer
2020 · Maria S. Dixon, Lhoucine Chdid, et al. · Cancer Epidemiology Biomarkers & Prevention
Abstract B116: Evaluating the ability of clinically approved chemotherapeutics to decrease race-associated breast cancer mortality disparities via targeting the tumor-promoting effect of Crystallin Beta B2
2020 · Portia L. Andrews, Denise K. Reaves, et al. · Cancer Epidemiology Biomarkers & Prevention
Abstract 4457: Determining the role of novel GLI1 splice variants in breast cancer
2018 · Maria S. Dixon, Lhoucine Chdid, et al. · Cancer Research
Abstract 4058: Race-associated breast cancer disparities: The role of CRYBB2 and its pseudogene
2018 · Maya A. Barrow, Megan E. Martin, et al. · Cancer Research
Abstract B49: Profiling of GLI antagonists in phenotypic models for effects on inflammatory breast cancer cell growth
2017 · Helen Oladapo, Scott Sauer, et al. · Cancer Epidemiology Biomarkers & Prevention
Works count: 24
Citation count: 401
H-index: 7
I10-index: 7
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