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Laura Orellana

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
2018 · Zev A. Binder, Amy Haseley Thorne, et al. · Cancer Cell · 169
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
2019 · Jianhui Ma, Jorge A. Benitez, et al. · Cancer Cell · 157
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Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier
2019 · Laura Orellana · Frontiers in Molecular Biosciences · 121
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Correlated motions are a fundamental property of β-sheets
2014 · R. Bryn Fenwick, Laura Orellana, et al. · Nature Communications · 103
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FlexServ: an integrated tool for the analysis of protein flexibility
2009 · Jordi Camps, Oliver Carrillo, et al. · Bioinformatics · 87
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Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations
2016 · Laura Orellana, Ozge Yoluk, et al. · Nature Communications · 81
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The molecular basis for sugar import in malaria parasites
2020 · Abdul Aziz Qureshi, Albert Suades, et al. · Nature · 77
Approaching Elastic Network Models to Molecular Dynamics Flexibility
2010 · Laura Orellana, Manuel Rueda, et al. · Journal of Chemical Theory and Computation · 72
Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9
2020 · Iven Winkelmann, Rei Matsuoka, et al. · The EMBO Journal · 65
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Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
2019 · Laura Orellana, Amy H. Thorne, et al. · Proceedings of the National Academy of Sciences · 59
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Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2
2022 · Rei Matsuoka, Roman Fudim, et al. · Nature Structural & Molecular Biology · 53
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Coarse-grained Representation of Protein Flexibility. Foundations, Successes, and Shortcomings
2011 · Modesto Orozco, Laura Orellana, et al. · Advances in protein chemistry and structural biology · 39
Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
2021 · Madhuranayaki Thulasingam, Laura Orellana, et al. · Nature Communications · 36
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Finding Conformational Transition Pathways from Discrete Molecular Dynamics Simulations
2012 · Pedro Sfriso, Agusti Emperador, et al. · Journal of Chemical Theory and Computation · 34
eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces
2019 · Laura Orellana, Johan Gustavsson, et al. · Bioinformatics · 23
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
2019 · Jianhui Ma, Jorge A. Benitez, et al. · Cancer Cell · 21
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
2019 · Jianhui Ma, Jorge A. Benitez, et al. · Cancer Cell · 17
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Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy
2019 · Laura Orellana · Molecular & Cellular Oncology · 11
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Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?
2023 · Laura Orellana · Applied Sciences · 10
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Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation
2014 · LAURA ORELLANA, MODESTO OROZCO · bioRxiv (Cold Spring Harbor Laboratory) · 8
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Genome sequencing in a cohort of 32 fetuses with genetic skeletal disorders
2025 · Hillevi Lindelöf, Anna Hammarsjö, et al. · European Journal of Human Genetics · 6
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Exploring the Conformational Impact of Glycine Receptor TM1-2 Mutations Through Coarse-Grained Analysis and Atomistic Simulations
2022 · Anil Ranu Mhashal, Ozge Yoluk, et al. · Frontiers in Molecular Biosciences · 6
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Clinical, genetic and structural delineation of RPL13-related spondyloepimetaphyseal dysplasia suggest extra-ribosomal functions of eL13
2023 · Prince Jacob, Hillevi Lindelöf, et al. · npj Genomic Medicine · 5
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Efficient sampling of large-scale transition pathways and intermediate conformations in sub-mesoscopic protein complexes
2026 · Domenico Scaramozzino, Byung Ho Lee, et al. · Nature Communications · 3
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Author Correction: Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2
2023 · Rei Matsuoka, Roman Fudim, et al. · Nature Structural & Molecular Biology · 3
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Works count: 55
Citation count: 1,273
H-index: 17
I10-index: 19
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