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Author

David Vı́lchez

Observed names: D Vilchez, D. Vilchez, D. Vílchez, David Vilchez, David Vílchez, Vilchez, David
Observed institutions: Salk Institute for Biological Studies, Howard Hughes Medical Institute, Consejo Superior de Investigaciones Científicas, University of Cologne, Ghent University, VIB-UGent Center for Plant Systems Biology, Hospital Clínic de Barcelona, Institute for Research in Biomedicine, Institut d'Investigacions Biomèdiques de Barcelona, Cluster of Excellence on Plant Sciences, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Parc Científic de Barcelona, Universitat de Barcelona, University of California, Berkeley
ORCID: 0000-0002-0801-0743
Observed ORCID: 0000-0002-0801-0743
OpenAlex ID: A5061493676
The role of protein clearance mechanisms in organismal ageing and age-related diseases
2014 · David Vilchez, Isabel Saez, et al. · Nature Communications · 689
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RPN-6 determines C. elegans longevity under proteotoxic stress conditions
2012 · David Vilchez, Ianessa Morantte, et al. · Nature · 409
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11
2012 · David Vilchez, Leah Boyer, et al. · Nature · 387
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
2007 · David Vilchez, Susana Ros, et al. · Nature Neuroscience · 376
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014 · Isabel Saez, David Vilchez · Current Genomics · 325
Regulation of glycogen synthesis by the laforin–malin complex is modulated by the AMP-activated protein kinase pathway
2007 · Maria Carmen Solaz-Fuster, José Vicente Gimeno-Alcañiz, et al. · Human Molecular Genetics · 145
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Proteostasis and aging of stem cells
2013 · David Vilchez, Milos S. Simic, et al. · Trends in Cell Biology · 143
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
2019 · Caroline Kumsta, Jessica T. Chang, et al. · Nature Communications · 140
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Rewiring of the ubiquitinated proteome determines ageing in C. elegans
2021 · Seda Koyuncu, Rute Loureiro, et al. · Nature · 134
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The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
2018 · Seda Koyuncu, Isabel Saez, et al. · Nature Communications · 103
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DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis
2020 · Arun Thiruvalluvan, Eduardo P. de Mattos, et al. · Molecular Cell · 90
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Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
2016 · Alireza Noormohammadi, Amirabbas Khodakarami, et al. · Nature Communications · 83
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A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
2017 · Hyun Ju Lee, Deniz Bartsch, et al. · Nature Communications · 72
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Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes
2023 · Hyun Ju Lee, Hafiza Alirzayeva, et al. · Nature Aging · 59
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Proteostasis of Huntingtin in Health and Disease
2017 · Seda Koyuncu, Azra Fatima, et al. · International Journal of Molecular Sciences · 58
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Insights into the ubiquitin-proteasome system of human embryonic stem cells
2018 · Isabel Saez, Seda Koyuncu, et al. · Scientific Reports · 56
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The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes
2016 · Markus M. Rinschen, Puneet Bharill, et al. · Human Molecular Genetics · 55
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Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans
2021 · Giuseppe Calculli, Hyun Ju Lee, et al. · Science Advances · 53
Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells
2017 · Alireza Noormohammadi, Giuseppe Calculli, et al. · Cellular and Molecular Life Sciences · 52
Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms
2020 · Sara Sarroca, Alaó Gatius, et al. · The Journal of Nutritional Biochemistry · 50
FOXO 4 is necessary for neural differentiation of human embryonic stem cells
2013 · David Vilchez, Leah Boyer, et al. · Aging Cell · 49
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Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans
2019 · Hyun Ju Lee, Alireza Noormohammadi, et al. · Nature Metabolism · 43
Protein clearance strategies for disease intervention
2021 · Franziska Hommen, Saygın Bilican, et al. · Journal of Neural Transmission · 41
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Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines
2004 · Rosa M Cristòfol, Sergi Gassó, et al. · Toxicology Letters · 37
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells
2020 · Azra Fatima, Dilber Irmak, et al. · Communications Biology · 36
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Works count: 89
Citation count: 4,205
H-index: 30
I10-index: 42
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