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Kenneth J. DiRico

Observed names: DiRico, K.J., Dirico, K., Dirico, Kenneth J., K Dirico, K. Dirico, K. J. DIRICO, K.J. Dirico, Ken DiRico, Ken Dirico, Kenneth DiRico, Kenneth Dirico, Kenneth J. Dirico
OpenAlex ID: A5063944697
Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor
2012 · Antonia F. Stepan, Chakrapani Subramanyam, et al. · Journal of Medicinal Chemistry · 468
Acoustic Ejection Mass Spectrometry for High-Throughput Analysis
2021 · Hui Zhang, Chang Liu, et al. · Analytical Chemistry · 124
Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors
2011 · Antonia F. Stepan, Kapil Karki, et al. · Journal of Medicinal Chemistry · 105
Concerted vs Stepwise Mechanisms in Dehydro-Diels–Alder Reactions
2011 · Aida Ajaz, Alexander Z. Bradley, et al. · The Journal of Organic Chemistry · 102
Strained Cyclic Cumulene Intermediates in Diels−Alder Cycloadditions of Enynes and Diynes
1996 · Richard C. Burrell, Kimberly J. Daoust, et al. · Journal of the American Chemical Society · 85
Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry
2020 · Kenneth J. DiRico, Wenyi Hua, et al. · ACS Medicinal Chemistry Letters · 84
Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads
2016 · Sujiet Puthenveetil, Frank Loganzo, et al. · Bioconjugate Chemistry · 66
3‘-Aminoadenosine-5‘-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A 3 Receptor
2002 · Michael P. DeNinno, Hiroko Masamune, et al. · Journal of Medicinal Chemistry · 59
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2
2009 · Jeffrey W. Corbett, Kevin D. Freeman-Cook, et al. · Bioorganic & Medicinal Chemistry Letters · 57
Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase
2011 · Kevin D. Freeman-Cook, Paul Amor, et al. · Journal of Medicinal Chemistry · 55
Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists
2009 · Paul S. Humphries, John W. Benbow, et al. · Bioorganic & Medicinal Chemistry Letters · 51
Ligand–Protein Interactions of Selective Casein Kinase 1δ Inhibitors
2013 · Scot Mente, Eric Arnold, et al. · Journal of Medicinal Chemistry · 33
Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
2012 · Michael P. DeNinno, Stephen W. Wright, et al. · Bioorganic & Medicinal Chemistry Letters · 27
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19
2023 · Christophe Allais, David Bernhardson, et al. · Organic Process Research & Development · 26
Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis
2010 · Amit S. Kalgutkar, David A. Griffith, et al. · Chemical Research in Toxicology · 25
Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists
2009 · Mary T. Didiuk, David A. Griffith, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Ab Initio Conformational Analysis of trans-Cyclohexene
1995 · Richard P. Johnson, Kenneth J. DiRico · The Journal of Organic Chemistry · 24
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
2007 · J.W. Corbett, K. Dirico, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Photorearrangements of acyclic conjugated enynes: a photochemical analog of the Bergman rearrangement
1993 · Manli Zheng, Kenneth J. DiRico, et al. · Journal of the American Chemical Society · 15
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor
2006 · Michael P. DeNinno, Hiroko Masamune, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones
2009 · Paul S. Humphries, Gayatri Balan, et al. · Tetrahedron Letters · 8
Synthesis of Unprotected Carboxy Indazoles via Pd-Catalyzed Carbonylation
2012 · Philip Wainwright, Remedios Perni, et al. · Synthetic Communications · 5
Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion
2011 · Francis Rajamohan, Eric Marr, et al. · Journal of Biological Chemistry · 5
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Corrigendum to “Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors” [Bioorg. Med. Chem. Lett. 17 (2007) 6707–6713]
2008 · J.W. Corbett, K. Dirico, et al. · Bioorganic & Medicinal Chemistry Letters · 2
C(sp2)–C(sp3) Suzuki–Miyaura Cross-Coupling Using gem-Bis(boronates)
2025 · Jun Xiao, Wen Xiu, et al. · The Journal of Organic Chemistry · 1
Works count: 40
Citation count: 1,490
H-index: 18
I10-index: 20
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