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Gordon W. Rewcastle

Observed names: G Rewcastle, G W Rewcastle, G. W. REWCASTLE, G. W. Rewcastle, G.W Rewcastle, G.W. Rewcastle, GORDON W REWCASTLE, GW Rewcastle, Gordon Rewcastle, Gordon W Rewcastle, Gordon William Rewcastle, Gordon W. Rewcastle, Rewcastle, G, Rewcastle, GW, Rewcastle, Gordon, Rewcastle, Gordon W.
ORCID: 0000-0001-9083-3214
Observed ORCID: 0000-0001-9083-3214
OpenAlex ID: A5065865758
Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor
1996 · Alexander J. Bridges, Hairong Zhou, et al. · Journal of Medicinal Chemistry · 321
Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of minimal DNA-intercalating agents which may not act via topoisomerase II
1990 · William A. Denny, Gordon W. Rewcastle, et al. · Journal of Medicinal Chemistry · 308
Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions
2000 · Jeff B. Smaill, Gordon W. Rewcastle, et al. · Journal of Medicinal Chemistry · 270
Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.
1995 · Gordon W. Rewcastle, William A. Denny, et al. · Journal of Medicinal Chemistry · 263
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling
2007 · Claire Chaussade, Gordon W. Rewcastle, et al. · Biochemical Journal · 222
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Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
1991 · Gordon W. Rewcastle, Graham J. Atwell, et al. · Journal of Medicinal Chemistry · 196
Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
1987 · Graham J. Atwell, Gordon W. Rewcastle, et al. · Journal of Medicinal Chemistry · 188
Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor
1999 · Jeff B. Smaill, Brian D. Palmer, et al. · Journal of Medicinal Chemistry · 177
A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
2011 · Stephen Jamieson, Jack U. Flanagan, et al. · Biochemical Journal · 165
Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor
1996 · Gordon W. Rewcastle, Brian D. Palmer, et al. · Journal of Medicinal Chemistry · 151
Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-, and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted Anticancer Agents
2002 · Swarna A. Gamage, Julie A. Spicer, et al. · Journal of Medicinal Chemistry · 150
Potential antitumor agents. 51. Synthesis and antitumor activity of substituted phenazine-1-carboxamides
1987 · Gordon W. Rewcastle, William A. Denny, et al. · Journal of Medicinal Chemistry · 125
Tyrosine Kinase Inhibitors. 10. Isomeric 4-[(3-Bromophenyl)amino]pyrido[d]- pyrimidines Are Potent ATP Binding Site Inhibitors of the Tyrosine Kinase Function of the Epidermal Growth Factor Receptor
1996 · Gordon W. Rewcastle, Brian D. Palmer, et al. · Journal of Medicinal Chemistry · 116
Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4-d]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors
1998 · Gordon W. Rewcastle, Donna K. Murray, et al. · Journal of Medicinal Chemistry · 113
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo
1989 · Gordon W. Rewcastle, Graham J. Atwell, et al. · Journal of Medicinal Chemistry · 113
Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs
2000 · Julie A. Spicer, Swarna A. Gamage, et al. · Journal of Medicinal Chemistry · 109
Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)
2011 · Gordon W. Rewcastle, Swarna A. Gamage, et al. · Journal of Medicinal Chemistry · 107
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents
1987 · Laurence P. G. Wakelin, Graham J. Atwell, et al. · Journal of Medicinal Chemistry · 105
Identification of a Unique Co-operative Phosphoinositide 3-Kinase Signaling Mechanism Regulating Integrin αIIbβ3 Adhesive Function in Platelets
2007 · Simone M. Schoenwaelder, Akiko Ono, et al. · Journal of Biological Chemistry · 103
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Tyrosine Kinase Inhibitors. 12. Synthesis and Structure−Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-d]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor
1997 · Gordon W. Rewcastle, Alexander J. Bridges, et al. · Journal of Medicinal Chemistry · 101
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides
1988 · Brian D. Palmer, Gordon W. Rewcastle, et al. · Journal of Medicinal Chemistry · 85
Potential antitumor agents. 46. Structure-activity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide
1986 · Gordon W. Rewcastle, Graham J. Atwell, et al. · Journal of Medicinal Chemistry · 83
Synthesis, antitumor activity, and DNA binding properties of a new derivative of amsacrine, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino) phenylamino]-4-acridinecarboxamide.
1984 · B C Baguley, W A Denny, et al. · PubMed · 81
Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells
2011 · Euphemia Leung, Ji Eun Kim, et al. · Cancer Biology & Therapy · 79
Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Dithiobis(1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor Protein Tyrosine Kinases
1995 · Brian D. Palmer, Gordon W. Rewcastle, et al. · Journal of Medicinal Chemistry · 72
Works count: 182
Citation count: 5,969
H-index: 41
I10-index: 94
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