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Giulia Bortolussi

Gene Therapy in Patients with the Crigler–Najjar Syndrome
2023 · Lorenzo D’Antiga, Ulrich Beuers, et al. · New England Journal of Medicine · 91
Life-Long Correction of Hyperbilirubinemia with a Neonatal Liver-Specific AAV-Mediated Gene Transfer in a Lethal Mouse Model of Crigler–Najjar Syndrome
2014 · Giulia Bortolussi, Lorena Zentillin, et al. · Human Gene Therapy · 87
Rescue of bilirubin‐induced neonatal lethality in a mouse model of Crigler‐Najjar syndrome type I by AAV9‐mediated gene transfer
2011 · Giulia Bortolussi, Lorena Zentilin, et al. · The FASEB Journal · 75
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A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome
2016 · Giuseppe Ronzitti, Giulia Bortolussi, et al. · Molecular Therapy — Methods & Clinical Development · 72
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Bilirubin‐Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double‐Strand Break Repair Pathways in Human Cells
2018 · Vipin Rawat, Giulia Bortolussi, et al. · Oxidative Medicine and Cellular Longevity · 69
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Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome
2018 · Fanny Collaud, Giulia Bortolussi, et al. · Molecular Therapy — Methods & Clinical Development · 66
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Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases
2019 · Alessia De Caneva, Fabiola Porro, et al. · JCI Insight · 62
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Promoterless gene targeting without nucleases rescues lethality of a Crigler‐Najjar syndrome mouse model
2017 · Fabiola Porro, Giulia Bortolussi, et al. · EMBO Molecular Medicine · 62
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Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model
2017 · Simone Vodret, Giulia Bortolussi, et al. · Journal of Neuroinflammation · 50
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Attenuation of neuro-inflammation improves survival and neurodegeneration in a mouse model of severe neonatal hyperbilirubinemia
2018 · Simone Vodret, Giulia Bortolussi, et al. · Brain Behavior and Immunity · 49
The Role of ABC Transporters in Protecting Cells from Bilirubin Toxicity
2009 · C. Bellarosa, G. Bortolussi, et al. · Current Pharmaceutical Design · 49
Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicityin vivo
2014 · Giulia Bortolussi, Gabriele Baj, et al. · Disease Models & Mechanisms · 43
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Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice
2015 · G Bortolussi, E Codarin, et al. · Cell Death and Disease · 39
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Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler–Najjar Syndrome Type I
2017 · L Bočkor, G Bortolussi, et al. · Gene Therapy · 34
A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene
2020 · Sem J. Aronson, Robert S. Bakker, et al. · Molecular Therapy — Methods & Clinical Development · 27
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Advances in understanding disease mechanisms and potential treatments for Crigler–Najjar syndrome
2018 · Giulia Bortolussi, Andrés Fernando Muro · Expert Opinion on Orphan Drugs · 27
Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia
2015 · Simone Vodret, Giulia Bortolussi, et al. · Scientific Reports · 26
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Long-term correction of ornithine transcarbamylase deficiency in Spf-Ash mice with a translationally optimized AAV vector
2020 · Giulia De Sabbata, Florence Boisgerault, et al. · Molecular Therapy — Methods & Clinical Development · 25
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Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice
2022 · Shinnosuke Tsuji, Calvin J. Stephens, et al. · Nature Biotechnology · 23
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Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
2020 · Xiaoxia Shi, Sem J. Aronson, et al. · Molecular Therapy — Methods & Clinical Development · 23
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Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1 -/- lethal mouse model of neonatal hyperbilirubinemia
2016 · Luka Bočkor, Giulia Bortolussi, et al. · Human Molecular Genetics · 20
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Experimental models assessing bilirubin neurotoxicity
2019 · Giulia Bortolussi, Andrés F. Muro · Pediatric Research · 18
Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice
2020 · Elvira Smeralda Famulari, Victor Navarro-Tableros, et al. · Scientific Reports · 16
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Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1−/− Mice: Impact on Redox Status and Metabolism
2021 · Giulia Bortolussi, Xiaoxia Shi, et al. · Antioxidants · 15
A metabolite-based resistance mechanism against malaria
2025 · Ana Figueiredo, Sonia Trikha Rastogi, et al. · Science · 14
Works count: 56
Citation count: 1,144
H-index: 20
I10-index: 28
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