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Katherine Tugusheva

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)
2004 · Shawn J. Stachel, Craig A. Coburn, et al. · Journal of Medicinal Chemistry · 278
A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid
2014 · Mary J. Savage, Juliya Kalinina, et al. · Journal of Neuroscience · 183
First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
2008 · Sethu Sankaranarayanan, Marie A. Holahan, et al. · Journal of Pharmacology and Experimental Therapeutics · 107
In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1
2007 · Sethu Sankaranarayanan, Eric A. Price, et al. · Journal of Pharmacology and Experimental Therapeutics · 103
Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease
2014 · Yuan Zhou, Ikuo Hayashi, et al. · PLoS ONE · 88
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Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)
2006 · Hemaka A. Rajapakse, Philippe G. Nantermet, et al. · Journal of Medicinal Chemistry · 83
β-Secretase Cleavage at Amino Acid Residue 34 in the Amyloid β Peptide Is Dependent upon γ-Secretase Activity
2003 · Xiao-Ping Shi, Katherine Tugusheva, et al. · Journal of Biological Chemistry · 74
Characterization of plasma β‐secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease
2012 · Guoxin Wu, Sethu Sankaranarayanan, et al. · Journal of Neuroscience Research · 68
Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase
2008 · James C. Barrow, Shaun R. Stauffer, et al. · Journal of Medicinal Chemistry · 60
Biochemical and cell-based assays for characterization of BACE-1 inhibitors
2005 · Beth L. Pietrak, Ming-Chih Crouthamel, et al. · Analytical Biochemistry · 48
Design and Synthesis of 2,3,5‐Substituted Imidazolidin‐4‐one Inhibitors of BACE‐1
2007 · James C. Barrow, Kenneth E. Rittle, et al. · ChemMedChem · 38
Novel mutations introduced at the β-site of amyloid β protein precursor enhance the production of amyloid β peptide by BACE1 in vitro and in cells
2005 · Xiao-Ping Shi, Katherine Tugusheva, et al. · Journal of Alzheimer s Disease · 36
Compounds That Bind APP and Inhibit Aβ Processing in Vitro Suggest a Novel Approach to Alzheimer Disease Therapeutics
2005 · Amy S. Espeseth, Min Xu, et al. · Journal of Biological Chemistry · 32
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
2015 · Melissa Egbertson, Georgia B. McGaughey, et al. · Bioorganic & Medicinal Chemistry Letters · 24
SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition
2010 · Hemaka A. Rajapakse, Philippe G. Nantermet, et al. · Bioorganic & Medicinal Chemistry Letters · 24
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors
2010 · Hong Zhu, Mary B. Young, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Identification of a small molecule β-secretase inhibitor that binds without catalytic aspartate engagement
2008 · Thomas G. Steele, Ivory D. Hills, et al. · Bioorganic & Medicinal Chemistry Letters · 19
P2‐043: A quantitative assay selective for amyloid oligomer species differentiates cerebrospinal fluid from Alzheimer's disease and age‐matched normal
2012 · Abigail Wolfe, Alexander McCampbell, et al. · Alzheimer s & Dementia · 3
P4‐304: Effects of elevated plasma cholesterol on CSF lipids and Alzheimer's disease CSF biomarkers in African green monkeys
2012 · Ikuo Hayashi, Ikuo Hayashi, et al. · Alzheimer s & Dementia
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P4‐075: Cholesterol ester transfer protein–deficient polymorphisms alter cerebrospinal fluid biomarkers and reduce Alzheimer's disease–related cognitive impairment in apolipoprotein E‐ε4 carriers
2012 · Ikuo Hayashi, Jacky Wong, et al. · Alzheimer s & Dementia
Cover Picture: Design and Synthesis of 2,3,5‐Substituted Imidazolidin‐4‐one Inhibitors of BACE‐1 (ChemMedChem 7/2007)
2007 · James C. Barrow, Kenneth E. Rittle, et al. · ChemMedChem
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Works count: 21
Citation count: 1,288
H-index: 17
I10-index: 17
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