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Tung O. Chan

Observed names: T O Chan, T. Chan, T. O. Chan, T.O. Chan, Tung Chan, Tung O Chan, Tung On Chan, Tung O. Chan, Tung O. Chan
Observed institutions: Cincinnati Children's Hospital Medical Center, Fox Chase Cancer Center, Kyushu University, University of British Columbia, Thomas Jefferson University, University of Calgary, University of Pittsburgh, Sidney Kimmel Cancer Center, University of Pittsburgh Medical Center, ARIAD Pharmaceuticals (United States), Center for Translational Medicine, Medical Institute of Bioregulation, Kyushu University, Wake Forest University Health Sciences, University of Glasgow, University of Pennsylvania, Temple University, University of Oulu
ORCID: 0000-0001-6574-9555
Observed ORCID: 0000-0001-6574-9555
OpenAlex ID: A5071958785
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
1995 · Thomas F Franke, Sung-Il Yang, et al. · Cell · 2,006
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AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999 · Tung O. Chan, Susan E. Rittenhouse, et al. · Annual Review of Biochemistry · 988
Akt activation by growth factors is a multiple-step process: the role of the PH domain
1998 · Alfonso Bellacosa, Tung O Chan, et al. · Oncogene · 547
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
1997 · Naheed N. Ahmed, H. Leighton Grimes, et al. · Proceedings of the National Academy of Sciences · 519
Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation
1997 · Warren G. King, Mark D. Mattaliano, et al. · Molecular and Cellular Biology · 425
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Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase
1996 · Ketaki Datta, Alfonso Bellacosa, et al. · Journal of Biological Chemistry · 279
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The Gfi-1 Proto-Oncoprotein Contains a Novel Transcriptional Repressor Domain, SNAG, and Inhibits G 1 Arrest Induced by Interleukin-2 Withdrawal
1996 · H. Leighton Grimes, Tung O. Chan, et al. · Molecular and Cellular Biology · 279
The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells
2010 · David Álvarez-Guardia, Xavier Palomer, et al. · Cardiovascular Research · 187
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Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.
1990 · J D Bjorge, T O Chan, et al. · Proceedings of the National Academy of Sciences · 180
TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model
2008 · Xavier Palomer, David Álvarez-Guardia, et al. · Cardiovascular Research · 177
Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.
2003 · Csaba Kari, Tung O Chan, et al. · PubMed · 170
AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation
1995 · Ketaki Datta, Thomas F. Franke, et al. · Molecular and Cellular Biology · 164
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Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
2002 · Tung O. Chan, Ulrich Rodeck, et al. · Cancer Cell · 146
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Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice With Tumor Necrosis Factor-α–Induced Cardiomyopathy
2004 · Yoshihiro Higuchi, Charles F. McTiernan, et al. · Circulation · 139
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PDK2: A Complex Tail in One Akt
2001 · Tung O. Chan, Philip N. Tsichlis · Science s STKE · 132
The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death
1996 · H. Leighton Grimes, C. Blake Gilks, et al. · Proceedings of the National Academy of Sciences · 103
Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
2011 · Tung O. Chan, Jin Zhang, et al. · Proceedings of the National Academy of Sciences · 86
Differential Roles of Akt, Rac, and Ral in R-Ras-Mediated Cellular Transformation, Adhesion, and Survival
1999 · Masako Osada, Tatyana Tolkacheva, et al. · Molecular and Cellular Biology · 86
Cooperative Regulation of p70S6 Kinase by Receptor Tyrosine Kinases and G Protein-Coupled Receptors Augments Airway Smooth Muscle Growth
2005 · Charlotte K. Billington, Kok C. Kong, et al. · Biochemistry · 66
Regulated Overexpression of the A 1 -Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function
2006 · Hajime Funakoshi, Tung O. Chan, et al. · Circulation · 57
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AKT and CDK5/p35 Mediate Brain-derived Neurotrophic Factor Induction of DARPP-32 in Medium Size Spiny Neurons in Vitro
2007 · Alexey Bogush, Steve Pedrini, et al. · Journal of Biological Chemistry · 56
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Cardioprotection afforded by NF-κB ablation is associated with activation of Akt in mice overexpressing TNF-α
2005 · Yoshihiro Higuchi, Tung O. Chan, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 52
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways
2000 · Elena V Rusyn, Evangeline R Reynolds, et al. · Oncogene · 51
Controlled and Cardiac-Restricted Overexpression of the Arginine Vasopressin V1A Receptor Causes Reversible Left Ventricular Dysfunction Through Gαq-Mediated Cell Signaling
2011 · Xue Li, Tung O. Chan, et al. · Circulation · 48
A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity
2013 · M.Iqbal Hossain, Carli L. Roulston, et al. · Journal of Biological Chemistry · 46
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Works count: 59
Citation count: 7,599
H-index: 33
I10-index: 46
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