Author

John A. Flygare

Observed names: Flygare, John A., J. A. FLYGARE, J. Flygare, J.A. Flygare, John A Flygare, John Flygare

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Observed institutions: Northwestern University, University of Iowa, Merck & Co., Inc., Rahway, NJ, USA (United States), Amgen (United States), Genentech, South Texas Accelerated Research Therapeutics, Tennessee Oncology, Colorado State University, Stanford University

OpenAlex ID: A5073714235

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

2007 · Eugene Varfolomeev, John W. Blankenship, et al. · Cell · 1,214

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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

2015 · Sophie M. Lehar, Thomas Pillow, et al. · Nature · 832

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1997 · Helena S.Y. Mancebo, Gary Lee, et al. · Genes & Development · 545

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Structure-guided design of a selective BCL-XL inhibitor

2013 · Guillaume Lessene, Peter E Czabotar, et al. · Nature Chemical Biology · 381

Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity

2014 · Zhi-Fu Tao, Lisa Hasvold, et al. · ACS Medicinal Chemistry Letters · 310

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

2012 · John A. Flygare, Maureen Beresini, et al. · Journal of Medicinal Chemistry · 249

Antibody‐Drug Conjugates for the Treatment of Cancer

2012 · John A. Flygare, Thomas H. Pillow, et al. · Chemical Biology & Drug Design · 232

Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer

2015 · Melissa R. Junttila, Weiguang Mao, et al. · Science Translational Medicine · 182

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

2006 · Kerry Zobel, Lan Wang, et al. · ACS Chemical Biology · 174

A Novel Anti-CD22 Anthracycline-Based Antibody–Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs

2015 · Shang-Fan Yu, Bing Zheng, et al. · Clinical Cancer Research · 168

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates

2016 · Leanna R. Staben, Stefan G. Koenig, et al. · Nature Chemistry · 154

Solid-Phase Synthesis of 2-Aminothiazoles

1998 · Patrick C. Kearney, Monica Fernandez, et al. · The Journal of Organic Chemistry · 148

Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor

2020 · Le Wang, George A. Doherty, et al. · ACS Medicinal Chemistry Letters · 142

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

2016 · Thomas H. Pillow, Jack D. Sadowsky, et al. · Chemical Science · 142

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A novel ruthenium-catalyzed tandem cyclization-reconstitutive addition of propargyl alcohols with allyl alcohols

1992 · Barry M. Trost, John A. Flygare · Journal of the American Chemical Society · 133

Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

2017 · David S. Hewings, John A. Flygare, et al. · FEBS Journal · 116

Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity

2017 · BinQing Wei, Janet Gunzner-Toste, et al. · Journal of Medicinal Chemistry · 108

Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

2014 · Thomas H. Pillow, Janet Tien, et al. · Journal of Medicinal Chemistry · 106

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

2009 · Chudi Ndubaku, Eugene Varfolomeev, et al. · ACS Chemical Biology · 99

Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)

2003 · Matthew C. Franklin, Saloumeh Kadkhodayan, et al. · Biochemistry · 95

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes

2018 · David S. Hewings, Johanna Heideker, et al. · Nature Communications · 84

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Small-molecule pan-IAP antagonists: a patent review

2010 · John A Flygare, Wayne J Fairbrother · Expert Opinion on Therapeutic Patents · 80

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

2017 · Thomas H. Pillow, Melissa Schutten, et al. · Molecular Cancer Therapeutics · 72

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

2011 · Brad E. Sleebs, Peter E. Czabotar, et al. · Journal of Medicinal Chemistry · 71

An Anti–CLL-1 Antibody–Drug Conjugate for the Treatment of Acute Myeloid Leukemia

2018 · Bing Zheng, Shang-Fan Yu, et al. · Clinical Cancer Research · 66

Works count: 103

Citation count: 6,752

H-index: 37

I10-index: 49