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Yingsi Chen

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity
2006 · Xin-Jie Chu, Wanda DePinto, et al. · Journal of Medicinal Chemistry · 118
In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials
2006 · Wanda DePinto, Xin-Jie Chu, et al. · Molecular Cancer Therapeutics · 106
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Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
2007 · Shaoqing Chen, Li Chen, et al. · Bioorganic & Medicinal Chemistry Letters · 55
Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes
2011 · Yimin Qian, Stanley J. Wertheimer, et al. · Journal of Medicinal Chemistry · 41
Identification of novel, potent and selective inhibitors of Polo-like kinase 1
2011 · Shaoqing Chen, David Bartkovitz, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS/MAPK/NF-κB signaling pathway in vivo and in vitro
2023 · Ziyin Li, Weizuo Liao, et al. · Food and Chemical Toxicology · 31
3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors
2003 · Jin-Jun Liu, Apostolos Dermatakis, et al. · Bioorganic & Medicinal Chemistry Letters · 29
RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: Synthesis and biological evaluation
2005 · Lee A. McDermott, Mary Simcox, et al. · Bioorganic & Medicinal Chemistry · 21
Purification and Characterization of Human α-Galactosidase A Expressed in Insect Cells Using a Baculovirus Vector
2000 · Yingsi Chen, Ming Jin, et al. · Protein Expression and Purification · 19
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors
2011 · Weiya Yun, Mushtaq Ahmad, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis
2006 · Lee A. McDermott, Brian Higgins, et al. · Bioorganic & Medicinal Chemistry Letters · 11
Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity
2024 · Yingsi Chen, Feifei Xu, et al. · Ecotoxicology and Environmental Safety · 6
Design, synthesis of 1,4-cyclohexyldiamine substituted diaminopyrimidines as selective inhibitors of CDK1, CDK2 and CDK4 and their in vitro and in vivo evaluation
2005 · Qingjie Ding, Nan Jiang, et al. · Cancer Research · 1
SAR of Melanin-concentration Hormone (MCH), an Important Regulatory Hormone in Feeding Behavior
2001 · Waleed Danho, Joseph Swistok, et al. · Springer eBooks
Works count: 14
Citation count: 487
H-index: 11
I10-index: 11
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