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Author

Karen E. Hedin

Observed names: K E Hedin, Karen E Hedin, Karen Hedin
ORCID: 0000-0003-1010-923X
Observed ORCID: 0000-0003-1010-923X
OpenAlex ID: A5073731572
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
2018 · Rosalie M. Sterner, Reona Sakemura, et al. · Blood · 621
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Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma
2006 · Yazan Alsayed, Hai Ngo, et al. · Blood · 478
CXCR4 Physically Associates with the T Cell Receptor to Signal in T Cells
2006 · Ashok Kumar, Troy D. Humphreys, et al. · Immunity · 250
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Cloning of a Xenopus laevis Inwardly Rectifying K+ Channel Subunit That Permits GIRK1 Expression of IKACh Currents in Oocytes
1996 · Karen E Hedin, Nancy F Lim, et al. · Neuron · 176
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PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB
2015 · Lavakumar Karyampudi, Purushottam Lamichhane, et al. · Cancer Research · 105
Specificity of receptor-G protein interactions: Searching for the structure behind the signal
1993 · Karen E. Hedin, Kevin Duerson, et al. · Cellular Signalling · 104
Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
2004 · Irene M. Ghobrial, Nancy D. Bone, et al. · Mayo Clinic Proceedings · 92
CXCR4 Chemokine Receptor Signaling Induces Apoptosis in Acute Myeloid Leukemia Cells via Regulation of the Bcl-2 Family Members Bcl-XL, Noxa, and Bak
2013 · Kimberly N. Kremer, Kevin L. Peterson, et al. · Journal of Biological Chemistry · 81
Distinct Role of ZAP-70 and Src Homology 2 Domain-Containing Leukocyte Protein of 76 kDa in the Prolonged Activation of Extracellular Signal-Regulated Protein Kinase by the Stromal Cell-Derived Factor-1α/CXCL12 Chemokine
2003 · Kimberly N Kremer, Troy D Humphreys, et al. · The Journal of Immunology · 72
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Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element
1997 · K E Hedin, M P Bell, et al. · The Journal of Immunology · 64
Coactosin-Like 1 Antagonizes Cofilin to Promote Lamellipodial Protrusion at the Immune Synapse
2014 · Joanna Kim, Michael J. Shapiro, et al. · PLoS ONE · 62
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Gα13 and Rho Mediate Endosomal Trafficking of CXCR4 into Rab11+ Vesicles upon Stromal Cell-Derived Factor-1 Stimulation
2010 · Ashok Kumar, Kimberly N Kremer, et al. · The Journal of Immunology · 62
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Characterization of the CXCR4 Signaling in Pancreatic Cancer Cells
2007 · Daniel D. Billadeau, Subrha Chatterjee, et al. · International Journal of Gastrointestinal Cancer · 59
Gi Proteins Use a Novel βγ- and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes
1999 · Karen E. Hedin, Michael P. Bell, et al. · Journal of Biological Chemistry · 51
Osteoblasts Protect AML Cells From SDF‐1‐Induced Apoptosis
2013 · Kimberly N. Kremer, Amel Dudakovic, et al. · Journal of Cellular Biochemistry · 48
Maturation Versus Death of Developing Double-Positive Thymocytes Reflects Competing Effects on Bcl-2 Expression and Can Be Regulated by the Intensity of CD28 Costimulation
2001 · David J McKean, Catherine J Huntoon, et al. · The Journal of Immunology · 41
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Haplotype-Independent Costimulation of IL-10 Secretion by SDF-1/CXCL12 Proceeds via AP-1 Binding to the Human IL-10 Promoter
2007 · Kimberly N Kremer, Ashok Kumar, et al. · The Journal of Immunology · 37
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Stromal Cell-Derived Factor-1 Signaling via the CXCR4-TCR Heterodimer Requires Phospholipase C-β3 and Phospholipase C-γ1 for Distinct Cellular Responses
2011 · Kimberly N Kremer, Ian C Clift, et al. · The Journal of Immunology · 36
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GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion
2018 · Brittney A. Dinkel, Kimberly N. Kremer, et al. · Journal of Biological Chemistry · 35
β-Arrestin1 and Distinct CXCR4 Structures Are Required for Stromal Derived Factor-1 to Downregulate CXCR4 Cell-Surface Levels in Neuroblastoma
2014 · Ian C. Clift, Adebowale O. Bamidele, et al. · Molecular Pharmacology · 27
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IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes
2015 · Adebowale O. Bamidele, Kimberly N. Kremer, et al. · The Journal of Cell Biology · 25
TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL
2017 · Kimberly N. Kremer, Brittney A. Dinkel, et al. · Blood · 24
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Chemokines: New, Key Players in the Pathobiology of Pancreatic Cancer
2002 · Karen E. Hedin · International Journal of Gastrointestinal Cancer · 23
Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts
2015 · Kimberly N. Kremer, Amel Dudakovic, et al. · Journal of Biological Chemistry · 21
A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy
2020 · Rosalie M. Sterner, Karen E. Hedin, et al. · Mayo Clinic Proceedings Innovations Quality & Outcomes · 18
Works count: 62
Citation count: 2,701
H-index: 23
I10-index: 28
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