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B.A. Appleton
Observed names:
Appleton Brent,
Appleton, Brent A.,
B. Appleton,
Brent A Appleton,
Brent A. Appleton,
Brent Appleton
show all 6
Observed institutions:
Novartis (Switzerland),
Harvard University,
Genentech,
University of Toronto,
Novartis (United States),
Dart NeuroScience (United States),
Casma Therapeutics (United States),
Novartis Institutes for BioMedical Research
show all 8
ORCID:
0000-0003-1136-5649
Observed ORCID:
0000-0003-1136-5649
OpenAlex ID:
A5073745226
A Specificity Map for the PDZ Domain Family
2008
·
Raffi Tonikian
, Yingnan Zhang
, et al.
·
PLoS Biology
·
476
PDF
Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
2009
·
Jenny Bostrom
, Shang-Fan Yu
, et al.
·
Science
·
370
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
2007
·
Brent A Appleton
, Ping Wu
, et al.
·
The EMBO Journal
·
216
PDF
Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes
2009
·
Andreas Lingel
, Thomas M. Weiss
, et al.
·
Structure
·
212
PDF
Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains
2007
·
Pierre A. Barthelemy
, Helga Raab
, et al.
·
Journal of Biological Chemistry
·
179
Inhibition of Wnt signaling by Dishevelled PDZ peptides
2009
·
Yingnan Zhang
, Brent A Appleton
, et al.
·
Nature Chemical Biology
·
161
GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis
2021
·
Jonathan M. Goodwin
, Ward G. Walkup
, et al.
·
Science Advances
·
135
A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
2011
·
Ralph Tiedt
, Elisa Degenkolbe
, et al.
·
Cancer Research
·
134
PDF
The Crystal Structure of Murine Coronin-1: A Regulator of Actin Cytoskeletal Dynamics in Lymphocytes
2006
·
Brent A. Appleton
, Ping Wu
, et al.
·
Structure
·
120
PDF
Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families
2006
·
Yingnan Zhang
, Sherry Yeh
, et al.
·
Journal of Biological Chemistry
·
107
PDF
The Cytomegalovirus DNA Polymerase Subunit UL44 Forms a C Clamp-Shaped Dimer
2004
·
Brent A. Appleton
, Arianna Loregian
, et al.
·
Molecular Cell
·
99
PDF
Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3
2007
·
Steven T. Runyon
, Yingnan Zhang
, et al.
·
Protein Science
·
96
PDF
Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers
2014
·
Ida Aronchik
, Brent A. Appleton
, et al.
·
Molecular Cancer Research
·
82
Comparative Structural Analysis of the Erbin PDZ Domain and the First PDZ Domain of ZO-1
2006
·
Brent A. Appleton
, Yingnan Zhang
, et al.
·
Journal of Biological Chemistry
·
82
PDF
A Structural Portrait of the PDZ Domain Family
2014
·
Andreas Ernst
, Brent A. Appleton
, et al.
·
Journal of Molecular Biology
·
80
Discovery of Potent and Selective RSK Inhibitors as Biological Probes
2015
·
Rama Jain
, Michelle Mathur
, et al.
·
Journal of Medicinal Chemistry
·
75
Residues of Human Cytomegalovirus DNA Polymerase Catalytic Subunit UL54 That Are Necessary and Sufficient for Interaction with the Accessory Protein UL44
2003
·
Arianna Loregian
, Brent A. Appleton
, et al.
·
Journal of Virology
·
75
Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain
2007
·
Yingnan Zhang
, Brent A. Appleton
, et al.
·
Protein Science
·
66
PDF
Crystal Structure of the Cytomegalovirus DNA Polymerase Subunit UL44 in Complex with the C Terminus from the Catalytic Subunit
2005
·
Brent A. Appleton
, Justin Brooks
, et al.
·
Journal of Biological Chemistry
·
61
PDF
Specific Residues in the Connector Loop of the Human Cytomegalovirus DNA Polymerase Accessory Protein UL44 Are Crucial for Interaction with the UL54 Catalytic Subunit
2004
·
Arianna Loregian
, Brent A. Appleton
, et al.
·
Journal of Virology
·
60
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma
2015
·
Teresa E. Williams
, Sharadha Subramanian
, et al.
·
ACS Medicinal Chemistry Letters
·
55
Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
2017
·
Gisele A. Nishiguchi
, Alice Rico
, et al.
·
Journal of Medicinal Chemistry
·
45
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
2019
·
Savithri Ramurthy
, Benjamin R. Taft
, et al.
·
Journal of Medicinal Chemistry
·
42
Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity
2018
·
Colin K. Skepper
, Robert J. Moreau
, et al.
·
Journal of Medicinal Chemistry
·
32
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria
2018
·
Robert J. Moreau
, Colin K. Skepper
, et al.
·
Journal of Medicinal Chemistry
·
31
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Works count:
93
Citation count:
3,198
H-index:
26
I10-index:
30
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