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Tadas Sean Vasaitis

Observed names: T. Sean Vasaitis, T. Vasaitis, Tadas S Vasaitis, Tadas S. Vasaitis, Tadas Vasaitis
OpenAlex ID: A5073773238
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model
2005 · Venkatesh D. Handratta, Tadas S. Vasaitis, et al. · Journal of Medicinal Chemistry · 248
CYP17 inhibitors for prostate cancer therapy
2010 · Tadas S. Vasaitis, Robert D. Bruno, et al. · The Journal of Steroid Biochemistry and Molecular Biology · 215
Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases
2006 · Vincent C.O. Njar, Lalji Gediya, et al. · Bioorganic & Medicinal Chemistry · 147
Androgen receptor inactivation contributes to antitumor efficacy of 17α-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
2008 · Tadas Vasaitis, Aashvini Belosay, et al. · Molecular Cancer Therapeutics · 135
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Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer
2013 · Puranik Purushottamachar, Abhijit M. Godbole, et al. · Journal of Medicinal Chemistry · 105
Three Dimensional Pharmacophore Modeling of Human CYP17 Inhibitors. Potential Agents for Prostate Cancer Therapy
2003 · Omoshile O. Clement, Clive M. Freeman, et al. · Journal of Medicinal Chemistry · 83
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): Head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model
2011 · Robert D. Bruno, Tadas S. Vasaitis, et al. · Steroids · 76
Mechanistic Relationship between Androgen Receptor Polyglutamine Tract Truncation and Androgen-dependent Transcriptional Hyperactivity in Prostate Cancer Cells
2004 · Qianben Wang, T.S. Udayakumar, et al. · Journal of Biological Chemistry · 51
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
2007 · Vânia M.A. Moreira, Tadas S. Vasaitis, et al. · Steroids · 44
CYP17 Inhibitors for Prostate Cancer Treatment – An Update
2008 · V. Moreira, J. Salvador, et al. · Current Medicinal Chemistry · 43
Evidence for Threshold Effects of 25-Hydroxyvitamin D on Glucose Tolerance and Insulin Resistance in Black and White Obese Postmenopausal Women
2014 · John D. Sorkin, Tadas Sean Vasaitis, et al. · Journal of Nutrition · 42
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Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent
2008 · Puranik Purushottamachar, Aakanksha Khandelwal, et al. · Bioorganic & Medicinal Chemistry · 39
Novel, Potent Anti-Androgens of Therapeutic Potential: Recent Advances and Promising Developments
2010 · Tadas S Vasaitis, Vincent C O Njar · Future Medicinal Chemistry · 38
Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo
2019 · Andrew K. Kwegyir-Afful, Senthilmurugan Ramalingam, et al. · Cancers · 31
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The Coffey Lecture: Steroidogenic enzyme inhibitors and hormone dependent cancer
2008 · Angela Brodie, Vincent Njar, et al. · Urologic Oncology Seminars and Original Investigations · 31
Synthesis of novel C17 steroidal carbamates
2008 · Vânia M.A. Moreira, Tadas S. Vasaitis, et al. · Steroids · 30
First pharmacophore-based identification of androgen receptor down-regulating agents: Discovery of potent anti-prostate cancer agents
2007 · Puranik Purushottamachar, Aakanksha Khandelwal, et al. · Bioorganic & Medicinal Chemistry · 28
The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
2019 · Senthilmurugan Ramalingam, Vidya P. Ramamurthy, et al. · Cancers · 27
Phytoalexins, miRNAs and Breast Cancer: A Review of Phytochemical-mediated miRNA Regulation in Breast Cancer
2013 · Syreeta L. Tilghman, Lyndsay V. Rhodes, et al. · Journal of Health Care for the Poor and Underserved · 26
Heart Failure Among Asian American Subpopulations
2024 · Yan Cheng, Adrienne N. Poon, et al. · JAMA Network Open · 14
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Evaluating and Reducing Subgroup Disparity in AI Models: An Analysis of Pediatric COVID-19 Test Outcomes
2024 · Alexander Libin, Jonah T. Treitler, et al. · medRxiv · 3
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C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells
2011 · Vânia M. Moreira, Jorge A. R. Salvador, et al. · European Journal of Pharmaceutical Sciences · 2
Prevalences of AI Bias in Adolescent Hospitalization Risk Prediction
2026 · Ryan Wu, Azadeh Miran, et al. · Communications in computer and information science
Knowledge, attitudes, and awareness toward cannabis use at a Historically Black University
2025 · Khaled Muhsen Hasan, Tadas Sean Vasaitis · Journal of Ethnicity in Substance Abuse
Association Between Social and Environmental Exposure and Chronic Disease Burden in the United States: An Explainable AI Analysis of the Center for Disease Control Environmental Justice Index
2025 · Jonah Treitler, Tadas Vasaitis, et al. · Springer proceedings in business and economics
Works count: 29
Citation count: 1,458
H-index: 19
I10-index: 20
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