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Daniel Spinks

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
2019 · Susan Wyllie, Stephen Brand, et al. · Proceedings of the National Academy of Sciences · 176
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Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
2011 · Stephen Brand, Laura A. T. Cleghorn, et al. · Journal of Medicinal Chemistry · 119
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening
2009 · Chidochangu P. Mpamhanga, Daniel Spinks, et al. · Journal of Medicinal Chemistry · 104
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Chemical Validation of Trypanothione Synthetase
2009 · Leah S. Torrie, Susan Wyllie, et al. · Journal of Biological Chemistry · 84
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Dissecting the essentiality of the bifunctional trypanothione synthetase‐amidase in Trypanosoma brucei using chemical and genetic methods
2009 · Susan Wyllie, Sandra L. Oza, et al. · Molecular Microbiology · 82
Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease
2005 · I. McPhee, L.C.D. Gibson, et al. · Biochemical Society Transactions · 82
Serotonin Reuptake Inhibition: An Update on Current Research Strategies
2002 · D. Spinks, G. Spinks · Current Medicinal Chemistry · 81
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei
2009 · Daniel Spinks, Emma J. Shanks, et al. · ChemMedChem · 62
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
2018 · Michael G. Thomas, Manu De Rycker, et al. · Journal of Medicinal Chemistry · 54
4-(Phenylsulfonyl)piperidines: Novel, Selective, and Bioavailable 5-HT2AReceptor Antagonists
2001 · Stephen R. Fletcher, Frank Burkamp, et al. · Journal of Medicinal Chemistry · 52
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1
2010 · Daniel Spinks, Han B. Ong, et al. · ChemMedChem · 48
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Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
2011 · Daniel Spinks, Leah S. Torrie, et al. · ChemMedChem · 47
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
2017 · Stephen Brand, Eun Jung Ko, et al. · Journal of Medicinal Chemistry · 46
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors
2007 · David R. Adams, Achamma Abraham, et al. · Bioorganic & Medicinal Chemistry Letters · 31
Biaryl acids: Novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2
1998 · J. Milton, M.J. Slater, et al. · Bioorganic & Medicinal Chemistry Letters · 26
Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
2015 · Daniel Spinks, Victoria Smith, et al. · ChemMedChem · 24
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Microwave promoted amination of 3-bromoisoxazoles
2004 · Jane E. Moore, Daniel Spinks, et al. · Tetrahedron Letters · 24
Screening a protein kinase inhibitor library against Plasmodium falciparum
2017 · Irene Hallyburton, Raffaella Grimaldi, et al. · Malaria Journal · 20
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Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity
2020 · Michael G. Thomas, Manu De Rycker, et al. · Journal of Medicinal Chemistry · 13
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The discovery and SAR of indoline-3-carboxamides—A new series of 5-HT6 antagonists
2010 · Mark Reid, Ian Carlyle, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Optimisation of the Anti‐Trypanosoma brucei Activity of the Opioid Agonist U50488
2011 · Victoria C. Smith, Laura A. T. Cleghorn, et al. · ChemMedChem · 9
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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
2023 · Laura A. T. Cleghorn, Richard J. Wall, et al. · Journal of Medicinal Chemistry · 7
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Serotonin Reuptake Inhibition: An Update on Current Research Strategies
2004 · D. Spinks, G. Spinks · Frontiers in Medicinal Chemistry - Online · 5
2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease
2018 · Michael G. Thomas, Manu De Rycker, et al. · Bioorganic & Medicinal Chemistry Letters · 4
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Synthesis of 3-Haloisoxazole Boronic Esters: Novel Heterocyclic Synthetic Intermediates Containing Independently Variable Functionality
2002 · Joseph P. Harrity, Jane E. Moore, et al. · Synlett · 4
Works count: 45
Citation count: 1,216
H-index: 18
I10-index: 20
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