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Massimiliano Fonsi

Observed names: Fonsi, M., M. Fonsi
ORCID: 0000-0003-4549-1483
Observed ORCID: 0000-0003-4549-1483
OpenAlex ID: A5076006178
Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors
2009 · Philip Jones, Sergio Altamura, et al. · Journal of Medicinal Chemistry · 325
Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
2014 · Mikhail Kalinichev, Emmanuel Le Poul, et al. · Journal of Pharmacology and Experimental Therapeutics · 71
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Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors
2008 · Ester Muraglia, Olaf Kinzel, et al. · Journal of Medicinal Chemistry · 53
Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties
2009 · Olaf Kinzel, Laura Llauger-Bufi, et al. · Journal of Medicinal Chemistry · 46
High-Throughput Microsomal Stability Assay for Screening New Chemical Entities in Drug Discovery
2008 · Massimiliano Fonsi, Maria V. Orsale, et al. · SLAS DISCOVERY · 43
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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2
2011 · Olaf Kinzel, Anna Alfieri, et al. · Bioorganic & Medicinal Chemistry Letters · 37
Intra-Articular Hyaluronic Acid and Chondroitin Sulfate: Pharmacokinetic Investigation in Osteoarthritic Rat Models
2019 · Massimiliano Fonsi, Abdel-Ilah El Amrani, et al. · Current Therapeutic Research · 36
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N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists
2011 · Ester Muraglia, Jesus M. Ontoria, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221
2019 · Maria Teresa Di Martino, Mariamena Arbitrio, et al. · Cancers · 22
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The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease
2010 · E. Monteagudo, M. Fonsi, et al. · Xenobiotica · 17
High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
2007 · Annalise Di Marco, Antonella Cellucci, et al. · Drug Metabolism and Disposition · 15
Optimization of a series of potent and selective ketone histone deacetylase inhibitors
2008 · Giovanna Pescatore, Olaf Kinzel, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
2017 · Shalenie P. den Braver-Sewradj, Michiel W. den Braver, et al. · European Journal of Pharmaceutical Sciences · 10
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Metabolism-related liabilities of a potent histone deacetylase (HDAC) inhibitor and relevance of the route of administration on its metabolic fate
2009 · M. Fonsi, F. Fiore, et al. · Xenobiotica · 7
Scaling approaches for the prediction of human clearance of LNA-i-mir-221: A retrospective validation
2024 · Massimiliano Fonsi, Jacques Fulbert, et al. · Current Research in Pharmacology and Drug Discovery · 4
Methoxy-ether and crown-ether derivatives of tetrahomodioxa- and octahomotetraoxacalix[4]arenes
2001 · Bernardo Masci, Stefano Saccheo, et al. · Acta Crystallographica Section C Crystal Structure Communications · 4
Extrahepatic Metabolism may Complicate the IVIVC in Rats
2014 · Massimiliano Fonsi · Drug Metabolism Letters · 2
Assessment of Allometric Scaling Methods for the Prediction of Human Pharmacokinetic of LNA ‐i‐ miR ‐221
2026 · Hadija Marchiori, Michele Schiavon, et al. · CPT Pharmacometrics & Systems Pharmacology
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Translational Pharmacokinetic-Pharmacodynamic Modeling Framework for Protein Degraders in Oncology Drug Discovery
2026 · Massimiliano Fonsi, Radha Ramakrishnan, et al. · Research Square
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Hepatic and thyroid effects of phenobarbital in the minipig
2018 · J. Boje Nielsen, J. Decorde, et al. · Toxicology Letters
Thyroid hormone perturbation in a minipig model
2018 · Pramila Singh, Jonas Boje Nielsen, et al. · Reproductive Toxicology
Basal hepatic CYP activities in albino (Sprague–Dawley) and pigmented (Long Evans) rats
2017 · Walid Touati, Pramila Singh, et al. · Toxicology Letters
Determination of thyroxine (T4) in mouse plasma by microsampling
2016 · P. Singh, J. Perron, et al. · Toxicology Letters
ChemInform Abstract: Methoxy‐ether and Crown‐ether Derivatives of Tetrahomodioxa‐ and Octahomotetraoxacalix[4]arenes
2001 · Bernardo Masci, Stefano Saccheo, et al. · ChemInform
CCDC 170206: Experimental Crystal Structure Determination
2001 · Masci, B., Saccheo, S., et al. · The Cambridge Structural Database
Works count: 28
Citation count: 729
H-index: 12
I10-index: 13
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