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Piet H. van der Graaf

Observed names: P H Van der Graaf, P H van der Graaf, P. H. van der Graaf, P.H. Van der Graaf, P.H. van der Graaf, Piet H Van Der Graaf, Piet H Van der Graaf, Piet H van der Graaf, Piet H. Graaf, Piet H. Van Der Graaf, Piet H. Van der Graaf, Piet Van der Graaf, Piet. H. van der Graaf, Pieter H. Van der Graaf, van der Graaf, P. H.
Observed institutions: Leiden University, Cincinnati Children's Hospital Medical Center, Pfizer (United States), Pfizer (United Kingdom), University of Kent, Life Prediction Technologies (Canada), Certara (United States), Applied BioPhysics (United States), AstraZeneca (Sweden), Simcyp (United Kingdom), Tetra Tech (Canada), Australia's Climate Simulator, Vrije Universiteit Amsterdam
ORCID: 0000-0003-1314-3484
Observed ORCID: 0000-0003-1314-3484
OpenAlex ID: A5077172862
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
2011 · Paul Morgan, Piet H. Van Der Graaf, et al. · Drug Discovery Today · 685
Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
2011 · Piet H. van der Graaf, Neil Benson · Pharmaceutical Research · 248
Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development
2013 · P A Milligan, M J Brown, et al. · Clinical Pharmacology & Therapeutics · 238
Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends
2017 · Thomas J. Snowden, Piet H. van der Graaf, et al. · Bulletin of Mathematical Biology · 150
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The role of mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modelling in translational research of biologics
2007 · Balaji M. Agoram, Steven W. Martin, et al. · Drug Discovery Today · 143
In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant
2016 · Wilhelmus E.A. de Witte, Meindert Danhof, et al. · Trends in Pharmacological Sciences · 120
Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach
2018 · Alison Betts, Anne Keunecke, et al. · mAbs · 113
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Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?
2013 · P Vicini, P H van der Graaf · Clinical Pharmacology & Therapeutics · 108
Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine
2017 · Isabelle Kohler, Thomas Hankemeier, et al. · European Journal of Pharmaceutical Sciences · 107
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CPT: Pharmacometrics and Systems Pharmacology
2012 · Piet H van der Graaf · CPT Pharmacometrics & Systems Pharmacology · 100
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Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy
2016 · Vasudev Kantae, Elke H. J. Krekels, et al. · Metabolomics · 95
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Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 end point
2013 · Emma C.Y. Hilton, Paul G. Baverel, et al. · Journal of Allergy and Clinical Immunology · 87
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A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®
2019 · Alison Betts, Nahor Haddish-Berhane, et al. · The AAPS Journal · 85
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Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Electroencephalogram Effects of GABAA Receptor Modulators: In Vitro-in Vivo Correlations
2003 · S.A.G. Visser, F.L.C. Wolters, et al. · Journal of Pharmacology and Experimental Therapeutics · 85
Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling
2009 · Bart A. Ploeger, Piet H. van der Graaf, et al. · Drug Metabolism and Pharmacokinetics · 78
Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm
2020 · Vijayalakshmi Chelliah, Georgia Lazarou, et al. · Clinical Pharmacology & Therapeutics · 76
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Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Synthetic Opioids in the Rat: Correlation with the Interaction at the Mu-Opioid Receptor
1998 · Eugène H. Cox, Thomas Kerbusch, et al. · Journal of Pharmacology and Experimental Therapeutics · 75
Mechanistic Quantitative Pharmacology Strategies for the Early Clinical Development of Bispecific Antibodies in Oncology
2020 · Alison Betts, Piet H. van der Graaf · Clinical Pharmacology & Therapeutics · 74
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Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of Antilipolytic Effects of Adenosine A1 Receptor Agonists in Rats: Prediction of Tissue-Dependent Efficacy In Vivo
1999 · P.H. Van der Graaf, E.A. Van Schaick, et al. · Journal of Pharmacology and Experimental Therapeutics · 72
Roadmap to 2030 for Drug Evaluation in Older Adults
2021 · Qi Liu, Janice B. Schwartz, et al. · Clinical Pharmacology & Therapeutics · 70
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Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude
2016 · Vasudev Kantae, Elke H.J. Krekels, et al. · Zebrafish · 67
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Systemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal Administration
2011 · Jasper Stevens, Bart A. Ploeger, et al. · Drug Metabolism and Disposition · 64
Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling.
1997 · P H Van der Graaf, M Danhof · PubMed · 63
Design principles of collateral sensitivity-based dosing strategies
2021 · Linda B. S. Aulin, Apostolos Liakopoulos, et al. · Nature Communications · 62
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Biomarker‐Guided Individualization of Antibiotic Therapy
2021 · Linda B.S. Aulin, Dylan W. de Lange, et al. · Clinical Pharmacology & Therapeutics · 62
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Works count: 236
Citation count: 6,024
H-index: 39
I10-index: 128
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