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Rhys Jones

Observed names: Jones, R.M., Jones, Rhys, R. Jones, Rhys M Jones, Rhys M. Jones
ORCID: 0000-0002-5263-9194
Observed ORCID: 0000-0002-5263-9194
OpenAlex ID: A5079565808
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
2021 · Britton Boras, Rhys M. Jones, et al. · Nature Communications · 424
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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
2021 · Kevin D. Freeman-Cook, Robert L. Hoffman, et al. · Journal of Medicinal Chemistry · 131
Challenges in inhaled product development and opportunities for open innovation
2010 · Ben Forbes, Bahman Asgharian, et al. · Advanced Drug Delivery Reviews · 108
Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses
2014 · Ben Forbes, Raegan O'Lone, et al. · Advanced Drug Delivery Reviews · 95
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
2023 · Shikhar Sharma, Chi-Yeh Chung, et al. · Cell chemical biology · 80
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Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators
2017 · Markus Boehm, Kevin Beaumont, et al. · Journal of Medicinal Chemistry · 71
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Chapter 5. Sulfonamide as an Essential Functional Group in Drug Design
2010 · Amit S. Kalgutkar, Rhys Jones, et al. · RSC drug discovery/RSC drug discovery series · 62
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
2016 · Peter Jones, R. Ian Storer, et al. · Journal of Medicinal Chemistry · 57
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Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity
2011 · Rhys M. Jones, Natasha Neef · Xenobiotica · 55
In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes
2023 · David Tess, George C. Chang, et al. · The AAPS Journal · 45
The sulfonamide group as a structural alert: A distorted story?
2008 · Dennis A Smith, Rhys M Jones · PubMed · 45
Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes
2020 · Christopher Keefer, George Chang, et al. · European Journal of Pharmaceutical Sciences · 42
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist
2011 · Charles E. Mowbray, Andrew S. Bell, et al. · Bioorganic & Medicinal Chemistry Letters · 38
The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists
2008 · Alan D. Brown, Mark E. Bunnage, et al. · Bioorganic & Medicinal Chemistry Letters · 34
Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer
2024 · Rebecca A. Gallego, Sujin Cho-Schultz, et al. · Journal of Medicinal Chemistry · 26
Design and application of locally delivered agonists of the adenosine A2Areceptor
2009 · Simon Mantell, Rhys Jones, et al. · Expert Review of Clinical Pharmacology · 24
Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis
2018 · Elnaz Menhaji-Klotz, Kevin D. Hesp, et al. · Journal of Medicinal Chemistry · 23
Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease
2008 · Simon J. Mantell, Peter T. Stephenson, et al. · Bioorganic & Medicinal Chemistry Letters · 23
A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats
2011 · Rhys M. Jones, Anthony Harrison · Xenobiotica · 19
Inhalation by design: Dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD
2010 · Lyn H. Jones, Helen Baldock, et al. · Bioorganic & Medicinal Chemistry Letters · 18
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma
2011 · David S. Millan, Stephen A. Ballard, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Molecular hybridization yields triazole bronchodilators for the treatment of COPD
2015 · Lyn H. Jones, Jane Burrows, et al. · Bioorganic & Medicinal Chemistry Letters · 10
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure–activity relationship (SAR)
2011 · M. Abid Masood, Matthew D. Selby, et al. · Bioorganic & Medicinal Chemistry Letters · 8
The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration
2023 · Narayan Cheruvu, Esther van Duijn, et al. · Drug Metabolism and Disposition · 7
Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD
2011 · Laura Hilton, Rachel Osborne, et al. · MedChemComm · 7
Works count: 38
Citation count: 1,478
H-index: 19
I10-index: 22
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