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Patrick Strout

OpenAlex ID: A5079613331
Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies
2017 · Jonathan Rios-Doria, Jay Harper, et al. · Cancer Research · 148
Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics
2016 · Pamela Thompson, Ryan Fleming, et al. · Journal of Controlled Release · 56
Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
2018 · Song Cho, Francesca Zammarchi, et al. · Molecular Cancer Therapeutics · 49
Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
2017 · Jay Harper, Christopher Lloyd, et al. · Molecular Cancer Therapeutics · 47
Selecting an Optimal Antibody for Antibody–Drug Conjugate Therapy: Internalization and Intracellular Localization
2013 · Jay Harper, Shenlan Mao, et al. · Methods in molecular biology · 39
Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody
2015 · Pamela Thompson, Binyam Bezabeh, et al. · Bioconjugate Chemistry · 29
Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer
2019 · Jason B. White, Ryan Fleming, et al. · mAbs · 24
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Evaluation of anti-cancer stem cell activity of the anti-DLL4 antibody MEDI0639 in a phase I clinical trial of SCLC.
2016 · Haifeng Bao, Xiaoru Chen, et al. · Journal of Clinical Oncology · 4
Abstract A49: Anti-DLL4 antibodies inhibit cancer stem cells in small cell lung cancer.
2013 · Patrick Strout, Martin Korade, et al. · Molecular Cancer Therapeutics · 2
Abstract A004: MEDI3726 (ADCT-401), a novel antibody-drug conjugate targeting PSMA, has potent in vivo antitumor activity in prostate cancer patient-derived xenograft models
2018 · Song Cho, Francesca Zammarchi, et al. · Cancer Research · 1
Abstract 4596: Antibody-drug conjugates bearing pyrrolobenzodiazepine or tubulysin payloads alter the tumor immune microenvironment and synergize with multiple immunotherapies
2017 · Jonathan Rios-Doria, Jay Harper, et al. · Cancer Research · 1
Abstract 5098: A mouse DLL4 cross-reactive variant of MEDI0639 disrupts functional vessel formation and inhibits tumor growth in preclinical models.
2013 · Song H. Cho, David W. Jenkins, et al. · Cancer Research · 1
Supplementary Data from Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
2023 · Jay Harper, Christopher Lloyd, et al.
Supplementary Methods from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
2023 · Song Cho, Francesca Zammarchi, et al.
Supplementary Figures S1-S7 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
2023 · Song Cho, Francesca Zammarchi, et al.
Supplementary Tables S1 to S4 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
2023 · Song Cho, Francesca Zammarchi, et al.
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Data from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
2023 · Song Cho, Francesca Zammarchi, et al.
Data from Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
2023 · Jay Harper, Christopher Lloyd, et al.
Data from Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4
2023 · Jay Harper, Christopher Lloyd, et al.
Data from Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies
2023 · Jonathan Rios-Doria, Jay Harper, et al.
Supplemental figures and legends from Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies
2023 · Jonathan Rios-Doria, Jay Harper, et al.
Data from Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies
2023 · Jonathan Rios-Doria, Jay Harper, et al.
Generation of a functional humanized Delta-like ligand 4 transgenic mouse model
2017 · John Wiseman, Pernilla Gregersson, et al. · Transgenic Research
Abstract B233: c-Met antagonist Avimer™ polypeptide that exhibits potent in vivo and in vitro inhibitor activity
2009 · Song Cho, Richard Smith, et al. · Molecular Cancer Therapeutics
Works count: 24
Citation count: 401
H-index: 7
I10-index: 7
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