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Sven G. Ruf

Observed names: Ruf, S.G., Ruf, Sven, S Ruf, S. G. Ruf, S. RUF, S. Ruf, Sven G Ruf, Sven Ruf, Sven G. Ruf
Institution: Sanofi (Germany)
ORCID: 0000-0002-2144-2663
Observed ORCID: 0000-0002-2144-2663
OpenAlex ID: A5079623049
The PROTACtable genome
2021 · Melanie Schneider, Chris J. Radoux, et al. · Nature Reviews Drug Discovery · 260
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
2018 · Aimo Kannt, Sridharan Rajagopal, et al. · Scientific Reports · 100
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Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling
2015 · Angelika F. Winkel, Christian K. Engel, et al. · Journal of Biological Chemistry · 100
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Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers
2020 · Michael Berger, John D. Herszman, et al. · Chemical Science · 69
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Photoredox‐Mediated Hydrogen Isotope Exchange Reactions of Amino‐Acids, Peptides, and Peptide‐Derived Drugs
2020 · Fabien Legros, Patricia Fernandez‐Rodriguez, et al. · Chemistry - A European Journal · 60
Long-Term Severe Diabetes Only Leads to Mild Cardiac Diastolic Dysfunction in Zucker Diabetic Fatty Rats
2012 · Anneleen Daniels, Dominik Linz, et al. · European Journal of Heart Failure · 58
Novel β-Amino Acid Derivatives as Inhibitors of Cathepsin A
2012 · Sven Ruf, Christian Buning, et al. · Journal of Medicinal Chemistry · 45
Organophosphorus Compounds. Part 151: Synthesis and Reactivity of a Novel Isophosphinoline Derivative
2000 · Sven G Ruf, Jochen Dietz, et al. · Tetrahedron · 43
Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity
2018 · Jiedong Qiu, Sibylle J. Hauske, et al. · Amino Acids · 41
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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
2018 · Sven Ruf, Mahanandeesha Siddappa Hallur, et al. · Bioorganic & Medicinal Chemistry Letters · 39
Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats
2016 · Dominik Linz, Mathias Hohl, et al. · Cardiovascular Research · 38
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels
2016 · Agnese Petrera, Johann Gassenhuber, et al. · Journal of Translational Medicine · 33
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Identification of High-Affinity P2Y12Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone
2012 · Gernot Zech, Gerhard Hessler, et al. · Journal of Medicinal Chemistry · 33
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
2022 · Sven Ruf, Sridharan Rajagopal, et al. · Scientific Reports · 29
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Identification and Synthesis of Novel Inhibitors of Acetyl-CoA Carboxylase with in Vitro and in Vivo Efficacy on Fat Oxidation
2010 · Stefanie Keil, Marco Müller, et al. · Journal of Medicinal Chemistry · 27
Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders
2021 · Aimo Kannt, Sridharan Rajagopal, et al. · Molecules · 23
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Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
2017 · Srinivasan Swaminathan, Swarnakumari Birudukota, et al. · Biochemical and Biophysical Research Communications · 21
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice
2020 · Mathias Hohl, Manuel Mayr, et al. · Journal of Biological Chemistry · 20
Inhibition of CatA: An Emerging Strategy for the Treatment of Heart Failure
2013 · Sven Ruf, Christian Buning, et al. · Future Medicinal Chemistry · 18
Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion
2019 · Mathias Hohl, Katharina Erb, et al. · JACC Basic to Translational Science · 17
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Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases
2014 · Herman A. Schreuder, Alexander Liesum, et al. · Biochemical and Biophysical Research Communications · 16
Organophosphorus Compounds, Part 149. Preparation of 1,3-Oxaphospholes by Transition Metal-Catalyzed Reactions of α-Diazo-β-dicarbonyl Compounds with tert-Butylphosphaacetylene
2000 · Sven G. Ruf, Andreas Mack, et al. · Synthesis · 15
Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects
2015 · Joachim Tillner, Anne Lehmann, et al. · Clinical Pharmacology in Drug Development · 14
Synthesis and Reactivity of a Polycyclic, Oxa-Bridged Phosphaalkene
2000 · Sven G. Ruf, Uwe Bergsträßer, et al. · European Journal of Organic Chemistry · 13
Organophosphorus Compounds. Part 144: 1 A Novel Approach to 1,3-Oxaphospholes from Phosphaalkynes and Isomünchnones
2000 · Sven G. Ruf, Uwe Bergsträßer, et al. · Tetrahedron · 13
Works count: 51
Citation count: 1,205
H-index: 18
I10-index: 26
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