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John Gatfield

Observed names: Gatfield, J., Gatfield, John, J Gatfield, J. Gatfield, JOHN GATFIELD, John Gatfield (302973)
Observed institutions: University of British Columbia, University of Basel, Cornell University, Centre for Human Drug Research, Stanford Medicine, Idorsia Pharmaceuticals Ltd (Switzerland), University of Tübingen, Actelion (Switzerland), Stanford University
ORCID: 0000-0003-1617-8500
Observed ORCID: 0000-0003-1617-8500
OpenAlex ID: A5079713627
Essential Role for Cholesterol in Entry of Mycobacteria into Macrophages
2000 · John Gatfield, Jean Pieters · Science · 616
Ancestral antibiotic resistance in Mycobacterium tuberculosis
2005 · Rowan P. Morris, Liem Nguyen, et al. · Proceedings of the National Academy of Sciences · 334
Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
2008 · Marc Iglarz, Christoph Binkert, et al. · Journal of Pharmacology and Experimental Therapeutics · 327
Evaluation of tert‐Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities
2015 · Matthias V. Westphal, Bernd T. Wolfstädter, et al. · ChemMedChem · 216
2-Imino-thiazolidin-4-one Derivatives as Potent, Orally Active S1P1Receptor Agonists
2010 · Martin H. Bolli, Stefan Abele, et al. · Journal of Medicinal Chemistry · 182
Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering
2008 · Philipp Mueller, Jan Massner, et al. · Nature Immunology · 168
Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells
2012 · John Gatfield, Celia Mueller Grandjean, et al. · PLoS ONE · 165
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Association of the Leukocyte Plasma Membrane with the Actin Cytoskeleton through Coiled Coil-mediated Trimeric Coronin 1 Molecules
2005 · John Gatfield, Imke Albrecht, et al. · Molecular Biology of the Cell · 136
Antigen 84, an Effector of Pleiomorphism inMycobacterium smegmatis
2007 · Liem Nguyen, Nicole Scherr, et al. · Journal of Bacteriology · 116
Hijacking the host: survival of pathogenic mycobacteria inside macrophages
2002 · Jean Pieters, John Gatfield · Trends in Microbiology · 112
Sphingosine 1-Phosphate (S1P) Receptor Agonists Mediate Pro-fibrotic Responses in Normal Human Lung Fibroblasts via S1P2 and S1P3 Receptors and Smad-independent Signaling
2013 · Katrin Sobel, Katalin Menyhart, et al. · Journal of Biological Chemistry · 98
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Discovery and Characterization of ACT‐335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist
2013 · Michel A. Steiner, John Gatfield, et al. · ChemMedChem · 95
Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
2015 · Tetsuo Asaki, Keiichi Kuwano, et al. · Journal of Medicinal Chemistry · 93
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468
2017 · Alexander Treiber, Ruben de Kanter, et al. · Journal of Pharmacology and Experimental Therapeutics · 87
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Orexin Receptor Antagonists: A New Concept In CNS Disorders?
2010 · John Gatfield, Catherine Brisbare‐Roch, et al. · ChemMedChem · 71
RNA Interference in J774 Macrophages Reveals a Role for Coronin 1 in Mycobacterial Trafficking but Not in Actin-dependent Processes
2007 · Rajesh Jayachandran, John Gatfield, et al. · Molecular Biology of the Cell · 62
The Antifibrotic Activity of Prostacyclin Receptor Agonism Is Mediated through Inhibition of YAP/TAZ
2018 · Katarina Zmajkovicova, Katalin Menyhart, et al. · American Journal of Respiratory Cell and Molecular Biology · 53
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders
2020 · Christoph Boss, John Gatfield, et al. · ChemMedChem · 49
Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist
2014 · Christoph Boss, Catherine Roch‐Brisbare, et al. · ChemMedChem · 42
GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1
2020 · Katarina Zmajkovicova, Yasmina Bauer, et al. · PLoS ONE · 40
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Efficient replication of adenovirus despite the overexpression of active and nondegradable p53.
2001 · P Koch, J Gatfield, et al. · PubMed · 40
Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential
2017 · John Gatfield, Katalin Menyhart, et al. · Journal of Pharmacology and Experimental Therapeutics · 35
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Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2
2015 · Thierry Sifferlen, Amandine Boller, et al. · Bioorganic & Medicinal Chemistry Letters · 34
FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction
2015 · Katrin Sobel, Lucile Monnier, et al. · Molecular Pharmacology · 33
Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors
2018 · Patrick Sieber, Anny Schäfer, et al. · PLoS ONE · 31
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Works count: 80
Citation count: 3,680
H-index: 27
I10-index: 44
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