Author

Jane Seagal

Observed names: J Seagal, J. Seagal

Observed institutions: Boston Children's Hospital, Harvard University, Tel Aviv University, Technion – Israel Institute of Technology, AbbVie (United States), Abbott (United States), Rappaport Family Institute for Research in the Medical Sciences

ORCID: 0000-0002-5959-5139

Observed ORCID: 0000-0002-5959-5139

OpenAlex ID: A5079723451

Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting

2006 · Stefano Casola, Giorgio Cattoretti, et al. · Proceedings of the National Academy of Sciences · 237

Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

2008 · Zhenyue Hao, Gordon S. Duncan, et al. · Immunity · 212

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Constitutive Canonical NF-κB Activation Cooperates with Disruption of BLIMP1 in the Pathogenesis of Activated B Cell-like Diffuse Large Cell Lymphoma

2010 · Dinis Pedro Calado, Baochun Zhang, et al. · Cancer Cell · 194

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Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade

2019 · Chien-Chun Steven Pai, John T. Huang, et al. · Immunity · 140

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity

2018 · Chien-Chun Steven Pai, Donald M. Simons, et al. · Journal of Clinical Investigation · 135

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LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1

2007 · Julia Rastelli, Cornelia Hömig-Hölzel, et al. · Blood · 129

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IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β

2007 · Ari Waisman, Manfred Kraus, et al. · The Journal of Experimental Medicine · 129

BCR-dependent lineage plasticity in mature B cells

2019 · Robin Graf, Jane Seagal, et al. · Science · 104

Antiviral Drug Discovery for the Treatment of COVID-19 Infections

2022 · Teresa I. Ng, Ivan Correia, et al. · Viruses · 96

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Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

2022 · Katherine G. Nabel, Sarah A. Clark, et al. · Science · 79

Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration

2001 · Yehudit Kraizer, Nidal Mawasi, et al. · Biochemical and Biophysical Research Communications · 67

Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus

2019 · Stuart J Perper, Susan V Westmoreland, et al. · The Journal of Immunology · 41

A Fail-safe Mechanism for Negative Selection of Isotype-switched B Cell Precursors Is Regulated by the Fas/FasL Pathway

2003 · Jane Seagal, Efrat Edry, et al. · The Journal of Experimental Medicine · 39

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IL ‐36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis

2018 · Zhi Su, Stephanie Paulsboe, et al. · Experimental Dermatology · 33

A Novel Recombinant Fusion Protein Encoding a 20-Amino Acid Residue of the Third Extracellular (E3) Domain of CCR2 Neutralizes the Biological Activity of CCL2

2009 · Liat Izhak, Gizi Wildbaum, et al. · The Journal of Immunology · 26

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Role of Receptor Revision in Forming a B Cell Repertoire

2002 · Jane Seagal, Doron Melamed · Clinical Immunology · 16

Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Ig -deficient/lpr mice

2003 · J. Seagal · International Immunology · 15

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A novel allele for inducible Cre expression in germinal center B cells

2018 · Timm Weber, Jane Seagal, et al. · European Journal of Immunology · 11

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Cytoplasmic Igα Serine/Threonines Fine-Tune Igα Tyrosine Phosphorylation and Limit Bone Marrow Plasma Cell Formation

2011 · Heide Christine Patterson, Manfred Kraus, et al. · The Journal of Immunology · 10

Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Ig -deficient/lpr mice

2004 · J. Seagal · International Immunology · 8

Contribution of αβ and γδ T cells to the generation of primary immunoglobulin G‐driven autoimmune response in immunoglobulin‐µ‐deficient/lpr mice

2004 · Jane Seagal, Doron Melamed · Immunology · 7

Selection events in directing B cell development.

2003 · J Seagal, D Melamed · PubMed · 6

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Use of Human CD4 Transgenic Mice for Studying Immunogenicity of HIV-1 Envelope Protein gp120

2001 · J. Seagal, E. Spectorman, et al. · Transgenic Research · 4

THU0222 Prophylactic and therapeutic administration of an ANTI-CD40 antagonist antibody blocks and reverses proteinuria and nephritis in NZB/W-F1 mice

2017 · S Perper, S Westmoreland, et al. · Annals of the Rheumatic Diseases · 1

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1184 A platform for tuning therapeutic efficacy of T-Cell-engaging bispecific antibodies

2023 · Jane Seagal, Arvin Akoopie, et al. · Regular and Young Investigator Award Abstracts

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Works count: 29

Citation count: 1,740

H-index: 16

I10-index: 19