Author

Marie‐Therese Schaeffer

Observed names: M T Schaeffer, M. T. Schaeffer, M.T. Schaeffer, MARIE‐THERESE SCHAEFFER, MT Schaeffer, Marie-Therese Schaeffer

Institution: Scripps Research Institute

Observed institutions: Scripps Research Institute, Merck & Co., Inc., Rahway, NJ, USA (United States), United States Department of Veterans Affairs, University of California San Diego

OpenAlex ID: A5081027129

Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line.

1990 · G Conn, D D Soderman, et al. · Proceedings of the National Academy of Sciences · 222

Full Pharmacological Efficacy of a Novel S1P1 Agonist That Does Not Require S1P-Like Headgroup Interactions

2008 · Pedro J. Gonzalez-Cabrera, Euijung Jo, et al. · Molecular Pharmacology · 127

Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor.

1991 · S Ortega, M T Schaeffer, et al. · Journal of Biological Chemistry · 105

Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice

2011 · Stuart M Cahalan, Pedro J Gonzalez-Cabrera, et al. · Nature Chemical Biology · 82

A sphingosine 1-phosphate receptor 2 selective allosteric agonist

2013 · Hideo Satsu, Marie-Therese Schaeffer, et al. · Bioorganic & Medicinal Chemistry · 69

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Disulfide Bonds are Neither Required, Present, Nor Compatible with Full Activity of Human Recombinant Acidic Fibroblast Growth Factor

1990 · David L. Linemeyer, John G. Menke, et al. · Growth Factors · 64

Molecular Basis of the Pharmacological Difference between Rat and Human Bombesin Receptor Subtype-3 (BRS-3)

2002 · Jie Liu, Zhege J. Lao, et al. · Biochemistry · 62

Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists

2005 · Christopher W. Plummer, Paul E. Finke, et al. · Bioorganic & Medicinal Chemistry Letters · 56

Ligand-Binding Pocket Shape Differences between Sphingosine 1-Phosphate (S1P) Receptors S1P1 and S1P3 Determine Efficiency of Chemical Probe Identification by Ultrahigh-Throughput Screening

2008 · Stephan C. Schürer, Steven J. Brown, et al. · ACS Chemical Biology · 51

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

2011 · Mariangela Urbano, Miguel Guerrero, et al. · Bioorganic & Medicinal Chemistry Letters · 39

Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists

2011 · Miguel Guerrero, Mariangela Urbano, et al. · Bioorganic & Medicinal Chemistry Letters · 36

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

2004 · Laura C. Meurer, Paul E. Finke, et al. · Bioorganic & Medicinal Chemistry Letters · 33

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists

2005 · John S. Debenham, Christina B. Madsen-Duggan, et al. · Bioorganic & Medicinal Chemistry Letters · 27

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor

2011 · Mariangela Urbano, Miguel Guerrero, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists

2011 · Miguel Guerrero, Mariangela Urbano, et al. · Bioorganic & Medicinal Chemistry Letters · 19

Discovery, design and synthesis of a selective S1P3 receptor allosteric agonist

2013 · Miguel Guerrero, Ramulu Poddutoori, et al. · Bioorganic & Medicinal Chemistry Letters · 18

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

2009 · John S. Debenham, Christina B. Madsen-Duggan, et al. · Bioorganic & Medicinal Chemistry Letters · 18

SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists

2012 · Miguel Guerrero, Mariangela Urbano, et al. · Bioorganic & Medicinal Chemistry Letters · 13

Structural Modifications of Acidic Fibroblast Growth Factor Alter Activity, Stability, and Heparin Dependence

1991 · KENNETH A. THOMAS, SAGRARIO ORTEGA, et al. · Annals of the New York Academy of Sciences · 13

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

2007 · Christina B. Madsen-Duggan, John S. Debenham, et al. · Bioorganic & Medicinal Chemistry Letters · 11

Desensitization of β3-adrenergic receptor- stimulated adenylyl cyclase activity and lipolysis in rats

1998 · Pasquale P. Vicario, Mari R. Candelore, et al. · Life Sciences · 11

A High-Throughput Glow-Type Aequorin Assay for Measuring Receptor-Mediated Changes in Intracellular Calcium Levels

2000 · S.E. George, M.T. Schaeffer, et al. · Analytical Biochemistry · 10

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

2012 · Mariangela Urbano, Miguel Guerrero, et al. · Bioorganic & Medicinal Chemistry Letters · 9

Use of Bioluminescent Aequorin for the Pharmacological Characterization of 5ht Receptors

1999 · M. T. Schaeffer, D. Cully, et al. · Journal of Receptors and Signal Transduction · 8

Unique subset of thymic epithelial cells defined by the expression of a novel neuroendocrine antigen

1988 · Robert E. Sobol, Douglas Burton, et al. · Cellular Immunology · 7

Works count: 62

Citation count: 1,152

H-index: 17

I10-index: 22