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Hinrich Abken

Observed names: Abken Hinrich, Abken, Hinrich, H Abken, H. ABKEN, H. Abken, HINRICH ABKEN
Observed institutions: Roche (Switzerland), National Institutes of Health, University of Bonn, University of Fribourg, University of Cape Town, University of Cologne, Center for Integrated Protein Science Munich, University of Münster, Helmholtz Munich, University Hospital Regensburg, Roche Pharma AG (Germany), National Institute of Environmental Health Sciences, Evangelisches Krankenhaus Kalk, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne, Leibniz Institute for Immunotherapy, ISREC Foundation, École Polytechnique Fédérale de Lausanne, University of Regensburg, University of Duisburg-Essen, Ludwig-Maximilians-Universität München
ORCID: 0000-0002-4302-3240
Observed ORCID: 0000-0002-4302-3240
OpenAlex ID: A5081176216
TRUCKs: the fourth generation of CARs
2015 · Markus Chmielewski, Hinrich Abken · Expert Opinion on Biological Therapy · 739
IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
2011 · Markus Chmielewski, Caroline Kopecky, et al. · Cancer Research · 562
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CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
2017 · Markus Chmielewski, Hinrich Abken · Cell Reports · 429
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Of CAR s and TRUCK s: chimeric antigen receptor ( CAR ) T cells engineered with an inducible cytokine to modulate the tumor stroma
2013 · Markus Chmielewski, Andreas A. Hombach, et al. · Immunological Reviews · 356
Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule
2001 · Andreas Hombach, Anja Wieczarkowiecz, et al. · The Journal of Immunology · 299
T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity
2004 · Markus Chmielewski, Andreas Hombach, et al. · The Journal of Immunology · 260
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Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
2007 · Barbara Savoldo, Cliona M. Rooney, et al. · Blood · 234
Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response
2010 · A Hombach, A A Hombach, et al. · Gene Therapy · 228
T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice
2013 · Karin Krebs, Nina Böttinger, et al. · Gastroenterology · 227
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Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity
2015 · Maarten A Ligtenberg, Dimitrios Mougiakakos, et al. · The Journal of Immunology · 218
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OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 + T cells
2012 · Andreas A. Hombach, Johannes Heiders, et al. · OncoImmunology · 200
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Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas
2008 · Anna Kruschinski, Andreas Moosmann, et al. · Proceedings of the National Academy of Sciences · 197
CAR–T cells and solid tumors: tuning T cells to challenge an inveterate foe
2012 · David E. Gilham, Reno Debets, et al. · Trends in Molecular Medicine · 179
TRUCKS, the fourth‐generation CAR T cells: Current developments and clinical translation
2020 · Markus Chmielewski, Hinrich Abken · Advances in Cell and Gene Therapy · 175
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T Cells Redirected Against Hepatitis B Virus Surface Proteins Eliminate Infected Hepatocytes
2008 · Felix Bohne, Markus Chmielewski, et al. · Gastroenterology · 175
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Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells
2013 · Markus Chmielewski, Andreas A. Hombach, et al. · Frontiers in Immunology · 168
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T Cells That Target Carcinoembryonic Antigen Eradicate Orthotopic Pancreatic Carcinomas Without Inducing Autoimmune Colitis in Mice
2012 · Markus Chmielewski, Olga Hahn, et al. · Gastroenterology · 149
Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28‐OX40 signalling
2011 · Andreas A. Hombach, Hinrich Abken · International Journal of Cancer · 146
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CD28 Costimulation Impairs the Efficacy of a Redirected T-cell Antitumor Attack in the Presence of Regulatory T cells Which Can Be Overcome by Preventing Lck Activation
2011 · David M Kofler, Markus Chmielewski, et al. · Molecular Therapy · 139
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CAR T cells transform to trucks: chimeric antigen receptor–redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer
2012 · Markus Chmielewski, Hinrich Abken · Cancer Immunology Immunotherapy · 136
The Analysis of Tyrosinase-Specific mRNA in Blood Samples of Melanoma Patients by RT-PCR Is Not a Useful Test for Metastic Tumor Progression
1997 · Uwe Reinhold, Hans-Christian Lüdtke-Handjery, et al. · Journal of Investigative Dermatology · 135
Rational development of high-affinity T-cell receptor-like antibodies
2009 · Guillaume Stewart-Jones, Andreas Wadle, et al. · Proceedings of the National Academy of Sciences · 129
Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies
2022 · D. Thomalla, L. Beckmann, et al. · Blood · 126
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Nanobody Based Dual Specific CARs
2018 · Stijn De Munter, Joline Ingels, et al. · International Journal of Molecular Sciences · 124
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Eradication of melanomas by targeted elimination of a minor subset of tumor cells
2011 · Patrick Schmidt, Caroline Kopecky, et al. · Proceedings of the National Academy of Sciences · 124
Works count: 390
Citation count: 13,630
H-index: 66
I10-index: 189
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