Author

Peter A. Hunt

Observed names: Hunt, Peter A., P Hunt, P. A. HUNT, P. HUNT, P. Hunt, Peter A Hunt, Peter Hunt

Observed institutions: Swarthmore College, Merck & Co., Inc., Rahway, NJ, USA (United States), Loughborough University, MSD (UK) Limited (United Kingdom), Optibrium (United Kingdom), Novartis (United Kingdom), Goucher College, Imperial College London

ORCID: 0000-0003-0380-1893

Observed ORCID: 0000-0003-0380-1893

OpenAlex ID: A5082329935

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

2000 · Mark S. Shearman, Dirk Beher, et al. · Biochemistry · 362

Molecular Transformations as a Way of Finding and Exploiting Consistent Local QSAR

2005 · Robert P. Sheridan, Peter Hunt, et al. · Journal of Chemical Information and Modeling · 93

WhichP450: a multi-class categorical model to predict the major metabolising CYP450 isoform for a compound

2018 · Peter A. Hunt, Matthew D. Segall, et al. · Journal of Computer-Aided Molecular Design · 80

Imputation of Assay Bioactivity Data Using Deep Learning

2019 · T. M. Whitehead, B. W. J. Irwin, et al. · Journal of Chemical Information and Modeling · 71

Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABAAReceptor Agonists at the α3Subunit

2005 · Michael G. N. Russell, Robert W. Carling, et al. · Journal of Medicinal Chemistry · 63

Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism Using Quantum Mechanical Simulations

2016 · Jonathan D. Tyzack, Peter A. Hunt, et al. · Journal of Chemical Information and Modeling · 60

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

2015 · Alexander Heifetz, Gebhard F. X. Schertler, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 41

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Predicting p K a Using a Combination of Semi-Empirical Quantum Mechanics and Radial Basis Function Methods

2020 · Peter Hunt, Layla Hosseini-Gerami, et al. · Journal of Chemical Information and Modeling · 34

1-Alkyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-alkyl-oximes: a new class of potent orally active muscarinic agonists related to arecoline

1991 · E Toja, C Bonetti, et al. · European Journal of Medicinal Chemistry · 34

Synthesis and Serotonergic Activity of 3-[2-(Pyrrolidin-1-yl)ethyl]indoles: Potent Agonists for the h5-HT1D Receptor with High Selectivity over the h5-HT1B Receptor

1999 · Francine Sternfeld, Alexander R. Guiblin, et al. · Journal of Medicinal Chemistry · 29

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

2011 · Thomas Hunt, Hazel C. Atherton-Watson, et al. · Bioorganic & Medicinal Chemistry Letters · 28

3-(Piperazinylpropyl)indoles: Selective, Orally Bioavailable h5-HT1DReceptor Agonists as Potential Antimigraine Agents

1999 · Mark S. Chambers, Leslie J. Street, et al. · Journal of Medicinal Chemistry · 28

Iodocyclisations of allyl- amidines and-ureas

1988 · Peter A. Hunt, Christopher May, et al. · Tetrahedron Letters · 28

Aminoalkyl phenyl sulfones—a novel series of 5-HT7 receptor ligands

2005 · Piotr Raubo, Margaret S. Beer, et al. · Bioorganic & Medicinal Chemistry Letters · 26

Interactions of water soluble porphyrins with Z-poly(dG-dC)

1986 · Robert F. Pasternack, David Sidney, et al. · Nucleic Acids Research · 26

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Predicting Regioselectivity of AO, CYP, FMO, and UGT Metabolism Using Quantum Mechanical Simulations and Machine Learning

2022 · Mario Öeren, Peter J. Walton, et al. · Journal of Medicinal Chemistry · 25

Structure and modeling in the design of β‐ and γ‐secretase inhibitors

2009 · M. Katharine Holloway, Peter Hunt, et al. · Drug Development Research · 23

FOCUS — Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists

2015 · Nikolaus Stiefl, Peter Gedeck, et al. · Journal of Chemical Information and Modeling · 22

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists

2013 · David W. Porter, Michelle Bradley, et al. · Bioorganic & Medicinal Chemistry Letters · 21

Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

2004 · Jonathan D. J. Wrigley, Emma J. Nunn, et al. · Journal of Neurochemistry · 21

Predicting reactivity to drug metabolism: beyond P450s—modelling FMOs and UGTs

2020 · Mario Öeren, Peter J. Walton, et al. · Journal of Computer-Aided Molecular Design · 20

The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists

2014 · David W. Porter, Michelle Bradley, et al. · Bioorganic & Medicinal Chemistry Letters · 20

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

2012 · Thomas Hunt, Hazel C. Atherton-Watson, et al. · Bioorganic & Medicinal Chemistry Letters · 18

Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases

2017 · Mike Petrassi, Rob Barber, et al. · Frontiers in Pharmacology · 17

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Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1 and 5-HT re-uptake ligands

1999 · Monique B. van Niel, Margaret S. Beer, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Works count: 55

Citation count: 1,337

H-index: 20

I10-index: 31