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Sofiya Leshchenko

High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains
2004 · Yunfeng Tie, Peter I. Boross, et al. · Journal of Molecular Biology · 230
Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance
2006 · Arun K. Ghosh, Perali Ramu Sridhar, et al. · Journal of Medicinal Chemistry · 155
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114
2006 · Andrey Y. Kovalevsky, Fengling Liu, et al. · Journal of Molecular Biology · 147
Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M
2006 · Andrey Yu. Kovalevsky, Yunfeng Tie, et al. · Journal of Medicinal Chemistry · 140
Stereoselective Photochemical 1,3-Dioxolane Addition to 5-Alkoxymethyl-2(5H)-furanone: Synthesis of Bis-tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94017 (TMC-114)
2004 · Arun K. Ghosh, Sofiya Leshchenko, et al. · The Journal of Organic Chemistry · 135
Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P 2 ′ -ligands
2006 · Arun K. Ghosh, Gary Schiltz, et al. · Bioorganic & Medicinal Chemistry Letters · 109
In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors
2010 · Yasuhiro Koh, Masayuki Amano, et al. · Journal of Virology · 95
Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies
2009 · Arun K. Ghosh, Sofiya Leshchenko-Yashchuk, et al. · Journal of Medicinal Chemistry · 65
Structure-Based Design: Synthesis and Biological Evaluation of a Series of Novel Cycloamide-Derived HIV-1 Protease Inhibitors
2005 · Arun K. Ghosh, Lisa M. Swanson, et al. · Journal of Medicinal Chemistry · 64
Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein–ligand X-ray studies
2008 · Arun K. Ghosh, Sandra Gemma, et al. · Organic & Biomolecular Chemistry · 16
Corrigendum to “Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114” [J. Mol. Biol. 363 (2006) 161–173]
2006 · Andrey Y. Kovalevsky, Fengling Liu, et al. · Journal of Molecular Biology
Design and Synthesis of Novel HIV‐1 Protease Inhibitors Incorporating Oxyindoles as the P2′‐Ligands.
2006 · Arun K. Ghosh, Gary Schiltz, et al. · ChemInform
Works count: 16
Citation count: 1,156
H-index: 10
I10-index: 10
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